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Telomere length is a critical determinant for survival in multiple myeloma

Lookup NU author(s): Professor Graham Jackson, Professor James Allan

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Abstract

© 2017 John Wiley & Sons Ltd. The variable clinical outcomes of Multiple Myeloma (MM) patients are incompletely defined by current prognostication tools. We examined the clinical utility of high-resolution telomere length analysis as a prognostic marker in MM. Cohort stratification, using a previously determined length threshold for telomere dysfunction, revealed that patients with short telomeres had a significantly shorter overall survival (P < 0·0001; HR = 3·4). Multivariate modelling using forward selection identified International Staging System (ISS) stage as the most important prognostic factor, followed by age and telomere length. Importantly, each ISS prognostic subset could be further risk-stratified according to telomere length, supporting the inclusion of this parameter as a refinement of the ISS.

Publication metadata

Author(s): Hyatt S, Jones RE, Heppel NH, Grimstead JW, Fegan C, Jackson GH, Hills R, Allan JM, Pratt G, Pepper C, Baird DM

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2017

Volume: 178

Issue: 1

Pages: 94-98

Print publication date: 01/07/2017

Online publication date: 24/03/2017

Acceptance date: 31/12/2016

Date deposited: 05/06/2017

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: John Wiley & Sons Ltd

URL: https://doi.org/10.1111/bjh.14643

DOI: 10.1111/bjh.14643

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