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Pathophysiology of GvHD and other HSCT-related major complications

Lookup NU author(s): Dr Emily Mavin, Dr Xiao WangORCiD, Professor Anne Dickinson



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2017 Ghimire, Weber, Mavin, Wang, Dickinson and Holler. For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve patient quality of life, and yet, complete success is hard to achieve. This review assimilates recent updates on pathophysiology of GvHD, prophylaxis and treatment of GvHD-related complications, and advances in the potential treatment of GvHD.

Publication metadata

Author(s): Ghimire S, Weber D, Mavin E, Wang XN, Dickinson AM, Holler E

Publication type: Review

Publication status: Published

Journal: Frontiers in Immunology

Year: 2017

Volume: 8

Online publication date: 20/03/2017

Acceptance date: 17/01/2017

ISSN (electronic): 1664-3224

Publisher: Frontiers Research Foundation


DOI: 10.3389/fimmu.2017.00079