Toggle Main Menu Toggle Search

Open Access padlockePrints

Telomeres and Cell Senescence - Size Matters Not

Lookup NU author(s): Stella Victorelli, Dr Joao Passos



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2017 The Authors. Telomeres are protective structures present at the ends of linear chromosomes that are important in preventing genome instability. Telomeres shorten as a result of cellular replication, leading to a permanent cell cycle arrest, also known as replicative senescence. Senescent cells have been shown to accumulate in mammalian tissue with age and in a number of age-related diseases, suggesting that they might contribute to the loss of tissue function observed with age. In this review, we will first describe evidence suggesting a key role for senescence in the ageing process and elaborate on some of the mechanisms by which telomeres can induce cellular senescence. Furthermore, we will present multiple lines of evidence suggesting that telomeres can act as sensors of both intrinsic and extrinsic stress as well as recent data indicating that telomere-induced senescence may occur irrespectively of the length of telomeres.

Publication metadata

Author(s): Victorelli S, Passos JF

Publication type: Article

Publication status: Published

Journal: EBioMedicine

Year: 2017

Volume: 21

Pages: 14-20

Print publication date: 01/07/2017

Online publication date: 21/03/2017

Acceptance date: 17/03/2017

Date deposited: 06/06/2017

ISSN (electronic): 2352-3964

Publisher: Elsevier BV


DOI: 10.1016/j.ebiom.2017.03.027


Altmetrics provided by Altmetric


Funder referenceFunder name