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Lookup NU author(s): Stella Victorelli, Dr Joao Passos
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2017 The Authors. Telomeres are protective structures present at the ends of linear chromosomes that are important in preventing genome instability. Telomeres shorten as a result of cellular replication, leading to a permanent cell cycle arrest, also known as replicative senescence. Senescent cells have been shown to accumulate in mammalian tissue with age and in a number of age-related diseases, suggesting that they might contribute to the loss of tissue function observed with age. In this review, we will first describe evidence suggesting a key role for senescence in the ageing process and elaborate on some of the mechanisms by which telomeres can induce cellular senescence. Furthermore, we will present multiple lines of evidence suggesting that telomeres can act as sensors of both intrinsic and extrinsic stress as well as recent data indicating that telomere-induced senescence may occur irrespectively of the length of telomeres.
Author(s): Victorelli S, Passos JF
Publication type: Article
Publication status: Published
Journal: EBioMedicine
Year: 2017
Volume: 21
Pages: 14-20
Print publication date: 01/07/2017
Online publication date: 21/03/2017
Acceptance date: 17/03/2017
Date deposited: 06/06/2017
ISSN (electronic): 2352-3964
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.ebiom.2017.03.027
DOI: 10.1016/j.ebiom.2017.03.027
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