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Lookup NU author(s): Professor John-Paul TaylorORCiD, Daniel Collerton, Dr Fiona LeBeau, Emeritus Professor Elaine Perry
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© Springer Japan KK 2017. Cholinergic dysfunction is a major feature of dementia with Lewy bodies (DLB) and makes a significant contribution to the cognitive impairment and other challenging symptoms seen in this condition. Despite this, or indeed, because of this, manipulation of the cholinergic system can offer significant therapeutic opportunities for treating DLB, and this is reflected in the fact that cholinesterase inhibitors remain one of our best treatments in this condition. In this chapter, we will explore the pathology of cholinergic dysfunction in DLB, review findings from both post-mortem and imaging studies and place this within a clinical framework.
Author(s): Taylor J-P, Collerton D, LeBeau F, Perry E
Editor(s): Kosaka K
Publication type: Book Chapter
Publication status: Published
Book Title: Dementia with Lewy Bodies: Clinical and Biological Aspects
Year: 2016
Pages: 23-39
Print publication date: 03/11/2016
Online publication date: 25/11/2016
Acceptance date: 02/04/2016
Publisher: Springer Japan
Place Published: Tokyo
URL: https://doi.org/10.1007/978-4-431-55948-1_3
DOI: 10.1007/978-4-431-55948-1_3
Notes: eISBN 9784431559481
Library holdings: Search Newcastle University Library for this item
ISBN: 9784431559467