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Cholinergic pathology in dementia with Lewy bodies

Lookup NU author(s): Professor John-Paul TaylorORCiD, Daniel Collerton, Dr Fiona LeBeau, Emeritus Professor Elaine Perry


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© Springer Japan KK 2017. Cholinergic dysfunction is a major feature of dementia with Lewy bodies (DLB) and makes a significant contribution to the cognitive impairment and other challenging symptoms seen in this condition. Despite this, or indeed, because of this, manipulation of the cholinergic system can offer significant therapeutic opportunities for treating DLB, and this is reflected in the fact that cholinesterase inhibitors remain one of our best treatments in this condition. In this chapter, we will explore the pathology of cholinergic dysfunction in DLB, review findings from both post-mortem and imaging studies and place this within a clinical framework.

Publication metadata

Author(s): Taylor J-P, Collerton D, LeBeau F, Perry E

Editor(s): Kosaka K

Publication type: Book Chapter

Publication status: Published

Book Title: Dementia with Lewy Bodies: Clinical and Biological Aspects

Year: 2016

Pages: 23-39

Print publication date: 03/11/2016

Online publication date: 25/11/2016

Acceptance date: 02/04/2016

Publisher: Springer Japan

Place Published: Tokyo


DOI: 10.1007/978-4-431-55948-1_3

Notes: eISBN 9784431559481

Library holdings: Search Newcastle University Library for this item

ISBN: 9784431559467