Cholinergic pathology in dementia with Lewy bodies

Taylor, J-P; Collerton, D; LeBeau, F; Perry, E

doi:10.1007/978-4-431-55948-1_3

Cholinergic pathology in dementia with Lewy bodies

Lookup NU author(s): Professor John-Paul Taylor ORCiD, Daniel Collerton, Dr Fiona LeBeau ORCiD, Emeritus Professor Elaine Perry

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Abstract

© Springer Japan KK 2017. Cholinergic dysfunction is a major feature of dementia with Lewy bodies (DLB) and makes a significant contribution to the cognitive impairment and other challenging symptoms seen in this condition. Despite this, or indeed, because of this, manipulation of the cholinergic system can offer significant therapeutic opportunities for treating DLB, and this is reflected in the fact that cholinesterase inhibitors remain one of our best treatments in this condition. In this chapter, we will explore the pathology of cholinergic dysfunction in DLB, review findings from both post-mortem and imaging studies and place this within a clinical framework.