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In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography

Lookup NU author(s): Professor David BrooksORCiD


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© 2017 International Parkinson and Movement Disorder Society Background: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction. Objectives: To describe tau aggregation in PD patients. Methods: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment. Results: Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0. Conclusion: Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. © 2017 International Parkinson and Movement Disorder Society.

Publication metadata

Author(s): Hansen AK, Damholdt MF, Fedorova TD, Knudsen K, Parbo P, Ismail R, Ostergaard K, Brooks DJ, Borghammer P

Publication type: Article

Publication status: Published

Journal: Movement Disorders

Year: 2017

Volume: 32

Issue: 6

Pages: 922-927

Print publication date: 01/06/2017

Online publication date: 03/03/2017

Acceptance date: 27/01/2017

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: John Wiley and Sons Inc.


DOI: 10.1002/mds.26961


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