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Lookup NU author(s): Professor Caroline Relton, Dr Paul Brennan
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© 2017 American Society for Nutrition. Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.
Author(s): Midttun O, Theofylaktopoulou D, McCann A, Fanidi A, Muller DC, Meyer K, Ulvik A, Zheng W, Shu X-O, Xiang Y-B, Prentice R, Thomson CA, Pettinger M, Giles GG, Hodge A, Cai Q, Blot WJ, Wu J, Johansson M, Hultdin J, Grankvist K, Stevens VL, McCullough ML, Weinstein SJ, Albanes D, Langhammer A, Hveem K, Naess M, Sesso HD, Gaziano JM, Buring JE, Lee I-M, Severi G, Zhang X, Han J, Stampfer MJ, Smith-Warner SA, Zeleniuch-Jacquotte A, Le Marchand L, Yuan J-M, Butler LM, Koh W-P, Wang R, Gao Y-T, Ericson U, Sonestedt E, Ziegler RG, Freedman ND, Visvanathan K, Jones MR, Relton C, Brennan P, Johansson M, Ueland PM
Publication type: Article
Publication status: Published
Journal: American Journal of Clinical Nutrition
Year: 2017
Volume: 105
Issue: 6
Pages: 1314-1326
Print publication date: 01/06/2017
Online publication date: 19/04/2017
Acceptance date: 02/04/2016
ISSN (print): 0002-9165
ISSN (electronic): 1938-3207
Publisher: American Society for Nutrition
URL: https://doi.org/10.3945/ajcn.116.151241
DOI: 10.3945/ajcn.116.151241
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