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Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases

Lookup NU author(s): Professor Ioakim SpyridopoulosORCiD

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Abstract

© 2017 Elsevier Inc. Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored. Non-coding RNAs (ncRNAs) comprise a heterogeneous family of RNA transcripts that regulate gene expression at the epigenetic, transcriptional, post-transcriptional, and post-translational levels. Non-coding RNAs have recently emerged as master modulators of T cell immunity. In this review, the state-of-the-art knowledge on ncRNA regulatory effects over T cell differentiation, function, and ageing in the context of age-associated CVDs, such as atherosclerosis, acute coronary syndromes, and heart failure, is discussed.

Publication metadata

Author(s): Coelho-Lima J, Spyridopoulos I

Publication type: Article

Publication status: Published

Journal: Experimental Gerontology

Year: 2018

Volume: 109

Pages: 38-46

Print publication date: 01/08/2018

Online publication date: 23/06/2017

Acceptance date: 20/06/2017

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.exger.2017.06.014

DOI: 10.1016/j.exger.2017.06.014

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