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Lookup NU author(s): Dr Emma KampourakiORCiD,
Dr Peter Avery,
Dr Hilary Wynne,
Dr Tina Biss,
Dr John Hanley,
Dr Katherine Talks,
Professor Farhad Kamali
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Blackwell Publishing Ltd, 2017.
For re-use rights please refer to the publisher's terms and conditions.
© 2017 John Wiley & Sons Ltd Current guidelines advocate using fixed-doses of oral vitamin K to reverse excessive anticoagulation in warfarinised patients who are either asymptomatic or have minor bleeds. Over-anticoagulated patients present with a wide range of International Normalised Ratio (INR) values and response to fixed doses of vitamin K varies. Consequently a significant proportion of patients remain outside their target INR after vitamin K administration, making them prone to either haemorrhage or thromboembolism. We compared the performance of a novel tailored vitamin K dosing regimen to that of a fixed-dose regimen with the primary measure being the proportion of over-anticoagulated patients returning to their target INR within 24 h. One hundred and eighty-one patients with an index INR > 6·0 (asymptomatic or with minor bleeding) were randomly allocated to receive oral administration of either a tailored dose (based upon index INR and body surface area) or a fixed-dose (1 or 2 mg) of vitamin K. A greater proportion of patients treated with the tailored dose returned to within target INR range compared to the fixed-dose regimen (68·9% vs. 52·8%; P = 0·026), whilst a smaller proportion of patients remained above target INR range (12·2% vs. 34·0%; P < 0·001). Individualised vitamin K dosing is more accurate than fixed-dose regimen in lowering INR to within target range in excessively anticoagulated patients.
Author(s): Kampouraki E, Avery PJ, Wynne H, Biss T, Hanley J, Talks K, Kamali F
Publication type: Article
Publication status: Published
Journal: British Journal of Haematology
Print publication date: 01/09/2017
Online publication date: 02/08/2017
Acceptance date: 29/03/2017
Date deposited: 30/11/2017
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141
Publisher: Blackwell Publishing Ltd
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