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The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease

Lookup NU author(s): Dr Marie Boyle, Dr Steven MassonORCiD, Professor Quentin AnsteeORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2017. Current medical practice artificially dichotomises a diagnosis of fatty liver disease into one of two common forms: alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Together, these account for the majority of chronic liver diseases worldwide. In recent years, there has been a dramatic increase in the prevalence of obesity and metabolic syndrome within the general population. These factors now coexist with alcohol consumption in a substantial proportion of the population. Each exposure sensitises the liver to the injurious effects of the other; an interaction that drives and potentially accelerates the genesis of liver disease. We review the epidemiological evidence and scientific literature that considers how alcohol consumption interacts with components of the metabolic syndrome to exert synergistic or super-additive effects on the development and progression of liver disease, before discussing how these interactions may be addressed in clinical practice.

Publication metadata

Author(s): Boyle M, Masson S, Anstee QM

Publication type: Article

Publication status: Published

Journal: Journal of Hepatology

Year: 2018

Volume: 68

Issue: 2

Pages: 251-267

Print publication date: 01/02/2018

Online publication date: 04/11/2017

Acceptance date: 01/11/2017

Date deposited: 21/12/2017

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641

Publisher: Elsevier BV


DOI: 10.1016/j.jhep.2017.11.006


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