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Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease

Lookup NU author(s): Professor Tiago OuteiroORCiD

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Abstract

© 2017 Elsevier Inc. Neurodegenerative diseases are highly debilitating conditions characterised primarily by progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) is one of the most common of these disorders, affecting 1–2% of the population above the age of 65. Although the underlying mechanisms of PD have been extensively studied, we still lack a full understanding of the molecular underpinnings of the disease. Thus, the in vitro and in vivo models currently used are able to only partially recapitulate the typical phenotypes of the disease. Here, we review various cell culture models currently used to study the molecular basis of PD, with a focus on alpha-synuclein-associated molecular pathologies. We also discuss how different cell models may constitute powerful tools for high-throughput screening of molecules capable of modulating alpha-synuclein toxicity.

Publication metadata

Author(s): Lázaro DF, Pavlou MAS, Outeiro TF

Publication type: Review

Publication status: Published

Journal: Experimental Neurology

Year: 2017

Volume: 298

Issue: Part B

Pages: 162-171

Print publication date: 01/12/2017

Online publication date: 16/05/2017

Acceptance date: 13/05/2017

ISSN (print): 0014-4886

ISSN (electronic): 1090-2430

Publisher: Academic Press Inc.

URL: https://doi.org/10.1016/j.expneurol.2017.05.007

DOI: 10.1016/j.expneurol.2017.05.007

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