Professor Tiago Outeiro
| Correlational assessment of the effects of JM-20 in a rat model of parkinsonism | 2025 |
|
Professor Tiago Outeiro
| α-Synuclein plastic antibody applied to monitor monomeric structures and discriminate aggregated forms in human CSF | 2025 |
|
Professor Tiago Outeiro
| A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria | 2024 |
|
Professor Tiago Outeiro
| A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease | 2024 |
|
Professor Tiago Outeiro
| A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as risk factors for synucleinopathies | 2024 |
|
Professor Tiago Outeiro
| Abandon the NAC in α-synuclein | 2024 |
|
Professor Tiago Outeiro
| Adsorption of alpha-synuclein and inhibition of fibril formation by nanocellulose and gold-coated-nanocellulose | 2024 |
|
Professor Tiago Outeiro
| Age-related alterations in efferent medial olivocochlear-outer hair cell and primary auditory ribbon synapses in CBA/J mice | 2024 |
|
Professor Tiago Outeiro
| Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions | 2024 |
|
Dr David Koss
Professor Tiago Outeiro
| Altered hippocampal doublecortin expression in Parkinson's disease | 2024 |
|
Professor Tiago Outeiro
| Automated Capillary Electrophoresis Immunoblot for the Detection of Alpha-Synuclein in Mouse Tissue | 2024 |
|
Professor Tiago Outeiro
| Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice | 2024 |
|
Professor Tiago Outeiro
| Cellular prion protein acts as mediator of amyloid beta uptake by caveolin-1 causing cellular dysfunctions in vitro and in vivo | 2024 |
|
Professor Tiago Outeiro
| Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments | 2024 |
|
Professor Tiago Outeiro
| Concerns with the new biological research criteria for synucleinopathy – Authors' reply | 2024 |
|
Professor Tiago Outeiro
| Correction to: Pharmacological Modulators of Tau Aggregation and Spreading (Brain Sciences, (2020), 10, 11, (858), 10.3390/brainsci10110858) | 2024 |
|
Professor Tiago Outeiro
| Diabetes and Parkinson's Disease: Understanding Shared Molecular Mechanisms | 2024 |
|
Professor Tiago Outeiro
| Editorial: One health care in psychiatric and neurological diseases | 2024 |
|
Professor Tiago Outeiro
| Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures | 2024 |
|
Professor Tiago Outeiro
| Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution | 2024 |
|
Professor Tiago Outeiro
| In silico analysis of alpha-synuclein protein variants and posttranslational modifications related to Parkinson's disease | 2024 |
|
Professor Tiago Outeiro
| Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1 | 2024 |
|
Professor Tiago Outeiro
| Novel multifunctional nanoliposomes inhibit α-synuclein fibrillization, attenuate microglial activation, and silence the expression of SNCA gene [Nuevos nanoliposomas multifuncionales inhiben la fibrilización de la α-sinucleína, atenúan la activación de la microglía y silencian la expresión de SNCA] | 2024 |
|
Professor Tiago Outeiro
| One-step nanoscale expansion microscopy reveals individual protein shapes | 2024 |
|
Professor Tiago Outeiro
| Physical Exercise-Induced Activation of NRF2 and BDNF as a Promising Strategy for Ferroptosis Regulation in Parkinson’s Disease | 2024 |
|
Professor Tiago Outeiro
| Prion meeting 2023: implications of a growing field | 2024 |
|
Professor Tiago Outeiro
| PrP meets alpha-synuclein: Molecular mechanisms and implications for disease | 2024 |
|
Professor Tiago Outeiro
| Reply to: “Rethinking Parkinson's Disease: A Syndromic Perspective” | 2024 |
|
Professor Tiago Outeiro
| Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis | 2024 |
|
Professor Tiago Outeiro
| Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid | 2024 |
|
Professor Tiago Outeiro
| SUMOylation modulates mitochondrial dynamics in an in vitro rotenone model of Parkinson's disease | 2024 |
|
Professor Tiago Outeiro
| Synthesis and Semi-Synthesis of Alpha-Synuclein: Insight into the Chemical Complexity of Synucleinopathies | 2024 |
|
Professor Tiago Outeiro
| Towards a biological diagnosis of PD | 2024 |
|
Professor Tiago Outeiro
| Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice | 2023 |
|
Professor Tiago Outeiro
| Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease | 2023 |
|
Professor Tiago Outeiro
| Corrigendum to “JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats” [Neurotoxicology 87 (2021) 70–85, (S0161813X21001029), (10.1016/j.neuro.2021.08.017)] | 2023 |
|
Professor Tiago Outeiro
Professor Johannes Attems
Professor Ian McKeith
| Defining the Riddle in Order to Solve It: There Is More Than One "Parkinson's Disease" | 2023 |
|
Professor Tiago Outeiro
| Editorial: Personalized care in neurological diseases | 2023 |
|
Professor Tiago Outeiro
| Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta-Analysis | 2023 |
|
Professor Tiago Outeiro
| Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage | 2023 |
|
Professor Tiago Outeiro
| Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria | 2023 |
|
Dr Tuomo Polvikoski
Professor Tiago Outeiro
Dr Ahmad Khundakar
| Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy | 2023 |
|
Professor Tiago Outeiro
| Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation | 2023 |
|
Professor Tiago Outeiro
| miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy | 2023 |
|
Professor Tiago Outeiro
| More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy | 2023 |
|
Professor Tiago Outeiro
| Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic | 2023 |
|
Professor Tiago Outeiro
| Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease | 2023 |
|
Professor Tiago Outeiro
| RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions | 2023 |
|
Professor Tiago Outeiro
| Targeting Biomolecular Condensation and Protein Aggregation against Cancer | 2023 |
|
Professor Tiago Outeiro
| The immune system in Parkinson's disease: From biology to diagnosis and therapeutic targets | 2023 |
|
Professor Tiago Outeiro
| Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts | 2023 |
|
Professor Tiago Outeiro
| Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease | 2023 |
|
Professor Tiago Outeiro
| A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity | 2022 |
|
Professor Tiago Outeiro
| Cellular Prion Protein Mediates α-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo | 2022 |
|
Professor Tiago Outeiro
| Ectosomes and exosomes modulate neuronal spontaneous activity | 2022 |
|
Professor Tiago Outeiro
| Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells | 2022 |
|
Professor Tiago Outeiro
| From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms | 2022 |
|
Professor Tiago Outeiro
| Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition | 2022 |
|
Professor Tiago Outeiro
| Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes | 2022 |
|
Professor Tiago Outeiro
| Hexokinase 2: The preferential target of trehalose-6-phosphate over hexokinase 1 | 2022 |
|
Professor Tiago Outeiro
| JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species | 2022 |
|
Professor Tiago Outeiro
| Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane | 2022 |
|
Professor Tiago Outeiro
| Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity | 2022 |
|
Professor Tiago Outeiro
| Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation | 2022 |
|
Professor Tiago Outeiro
| Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation | 2022 |
|
Dr David Koss
Dr Daniel Erskine
Dr Andrew Porter
Dr Pawel Palmowski
Professor Johannes Attems
et al. | Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies. | 2022 |
|
Chris Hatton
Dr David Koss
Dr Lauren Walker
Professor Tiago Outeiro
Professor Johannes Attems
et al. | Prion-like α-synuclein pathology in the brain of infants with Krabbe disease | 2022 |
|
Professor Tiago Outeiro
| Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight | 2022 |
|
Dr Daniel Erskine
Professor Johannes Attems
Professor Ian McKeith
Professor Tiago Outeiro
| α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity | 2022 |
|
Professor Tiago Outeiro
| Alpha-Synuclein Antibody Characterization: Why Semantics Matters | 2021 |
|
Professor Tiago Outeiro
| Alpha-synuclein oligomerization and aggregation: A model will always be a model | 2021 |
|
Professor Tiago Outeiro
| Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease | 2021 |
|
Professor Tiago Outeiro
| Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies | 2021 |
|
Professor Tiago Outeiro
| Cancer and Parkinson's Disease: Common Targets, Emerging Hopes | 2021 |
|
Professor Tiago Outeiro
| Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo | 2021 |
|
Professor Tiago Outeiro
| DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization | 2021 |
|
Professor Tiago Outeiro
| Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo | 2021 |
|
Professor Tiago Outeiro
| Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity | 2021 |
|
Dr David Koss
Professor Tiago Outeiro
| Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases | 2021 |
|
Professor Tiago Outeiro
| Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation | 2021 |
|
Professor Tiago Outeiro
| In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies | 2021 |
|
Professor Tiago Outeiro
| JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties | 2021 |
|
Professor Tiago Outeiro
| JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats | 2021 |
|
Dr Daniel Erskine
Dr David Koss
Professor Viktor Korolchuk
Professor Tiago Outeiro
Professor Johannes Attems
et al. | Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders | 2021 |
|
Dr David Koss
Odeta Bondarevaite
Professor Johannes Attems
Professor Tiago Outeiro
| RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies | 2021 |
|
Professor Tiago Outeiro
| Reply to: “Parkinson's Disease and COVID-19: Do We Need to Be More Patient?” | 2021 |
|
Professor Tiago Outeiro
| Small molecule fisetin modulates alpha-Synuclein aggregation | 2021 |
|
Professor Tiago Outeiro
| A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model | 2020 |
|
Professor Tiago Outeiro
| Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors | 2020 |
|
Professor Tiago Outeiro
| Are genetic and idiopathic forms of Parkinson's disease the same disease? | 2020 |
|
Professor Tiago Outeiro
| Bioprospection of natural sources of polyphenols with therapeutic potential for redox-related diseases | 2020 |
|
Professor Tiago Outeiro
| Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization | 2020 |
|
Professor Tiago Outeiro
| From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease | 2020 |
|
Professor Tiago Outeiro
| Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein | 2020 |
|
Professor Tiago Outeiro
| Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model | 2020 |
|
Professor Tiago Outeiro
| Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients | 2020 |
|
Professor Tiago Outeiro
| Mechanisms of alpha-synuclein toxicity: An update and outlook | 2020 |
|
Professor Tiago Outeiro
| Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies | 2020 |
|
Professor Tiago Outeiro
| Pharmacological modulators of tau aggregation and spreading | 2020 |
|
Professor Tiago Outeiro
| Protein trapping leads to altered synaptic proteostasis in synucleinopathies | 2020 |
|
Professor Tiago Outeiro
| Reply to: SARS-CoV-2 as a trigger of neurodegeneration: thinking ahead | 2020 |
|
Professor Tiago Outeiro
| SARS-CoV-2, immunosenescence and inflammaging: Partners in the COVID-19 crime | 2020 |
|
Dr David Koss
Professor Tiago Outeiro
| Synucleinopathies: Where we are and where we need to go | 2020 |
|
Professor Tiago Outeiro
| The courage to change science | 2020 |
|
Professor Tiago Outeiro
| The Interplay Between Proteostasis Systems and Parkinson's Disease | 2020 |
|
Professor Tiago Outeiro
| The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders | 2020 |
|
Dr David Koss
Professor Tiago Outeiro
| In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies | 2019 |
|
Professor Tiago Outeiro
| A2AR-induced transcriptional deregulation in astrocytes: An in vitro study | 2019 |
|
Professor Tiago Outeiro
| Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity | 2019 |
|
Professor Tiago Outeiro
| Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1 | 2019 |
|
Dr David Koss
Mary Johnson
Professor Johannes Attems
Professor Tiago Outeiro
| Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies | 2019 |
|
Professor Tiago Outeiro
Dr David Koss
Dr Daniel Erskine
Dr Lauren Walker
Abishek Umashankar
et al. | Dementia with Lewy bodies: an update and outlook | 2019 |
|
Professor Tiago Outeiro
| Epigenetics of the Synapse in Neurodegeneration | 2019 |
|
Professor Tiago Outeiro
| Glycation in Huntington's disease: A possible modifier and target for intervention | 2019 |
|
Professor Tiago Outeiro
| Investigating targets for neuropharmacological intervention by molecular dynamics simulations | 2019 |
|
Professor Tiago Outeiro
| Monitoring α-synuclein multimerization in vivo | 2019 |
|
Dr Thomas Meyer
Professor Johannes Attems
Professor Tiago Outeiro
| Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein | 2019 |
|
Professor Tiago Outeiro
| Seeding variability of different alpha synuclein strains in synucleinopathies | 2019 |
|
Professor Tiago Outeiro
| Spreading of α-synuclein and tau: A systematic comparison of the mechanisms involved | 2019 |
|
Professor Tiago Outeiro
| Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding | 2019 |
|
Professor Tiago Outeiro
| Synuclein Meeting 2019: where we are and where we need to go | 2019 |
|
Professor Tiago Outeiro
| The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration | 2019 |
|
Professor Tiago Outeiro
| The role of LRRK2 in cell signalling | 2019 |
|
Professor Tiago Outeiro
| The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism | 2019 |
|
Professor Tiago Outeiro
| Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function | 2018 |
|
Professor Tiago Outeiro
| Alpha-synuclein glycation and the action of anti-diabetic agents in Parkinson's disease | 2018 |
|
Professor Tiago Outeiro
| Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View | 2018 |
|
Professor Tiago Outeiro
| Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast | 2018 |
|
Professor Tiago Outeiro
| Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models | 2018 |
|
Professor Tiago Outeiro
| Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells | 2018 |
|
Professor Tiago Outeiro
| Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration | 2018 |
|
Professor Tiago Outeiro
| Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons | 2018 |
|
Professor Tiago Outeiro
| Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders: A systematic review | 2018 |
|
Professor Tiago Outeiro
| A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies | 2017 |
|
Professor Tiago Outeiro
| Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity | 2017 |
|
Professor Tiago Outeiro
| Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress | 2017 |
|
Professor Tiago Outeiro
| Building Bridges through Science | 2017 |
|
Professor Tiago Outeiro
| Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain | 2017 |
|
Professor Tiago Outeiro
| Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease | 2017 |
|
Professor Tiago Outeiro
| Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors | 2017 |
|
Professor Tiago Outeiro
| Contribution of Neuroepigenetics to Huntington’s Disease | 2017 |
|
Professor Tiago Outeiro
| Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics | 2017 |
|
Professor Tiago Outeiro
| Editorial: Molecular chaperones and neurodegeneration | 2017 |
|
Professor Tiago Outeiro
| Epigenetics in Parkinson’s Disease | 2017 |
|
Professor Tiago Outeiro
| Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies | 2017 |
|
Professor Tiago Outeiro
| Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy | 2017 |
|
Professor Tiago Outeiro
| Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats | 2017 |
|
Professor Tiago Outeiro
| Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways | 2017 |
|
Professor Tiago Outeiro
| Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson's disease | 2017 |
|
Professor Tiago Outeiro
| Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease | 2017 |
|
Professor Tiago Outeiro
| Phycocyanin protects against Alpha-Synuclein toxicity in yeast | 2017 |
|
Professor Tiago Outeiro
| Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease | 2017 |
|
Professor Tiago Outeiro
| Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity | 2017 |
|
Professor Tiago Outeiro
| Serum lipid alterations in GBA-associated Parkinson's disease | 2017 |
|
Professor Tiago Outeiro
| Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway | 2017 |
|
Professor Tiago Outeiro
| Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage | 2017 |
|
Professor Tiago Outeiro
| Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents | 2017 |
|
Professor Tiago Outeiro
| Synuclein misfolding as a therapeutic target | 2017 |
|
Professor Tiago Outeiro
| Tau deletion promotes brain insulin resistance | 2017 |
|
Professor Tiago Outeiro
| The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease | 2017 |
|
Professor Tiago Outeiro
| The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes | 2017 |
|
Professor Tiago Outeiro
| The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease | 2017 |
|
Professor Tiago Outeiro
| Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease | 2017 |
|
Professor Tiago Outeiro
| Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death | 2017 |
|
Professor Tiago Outeiro
| Yeast models of Parkinson's disease-associated molecular pathologies | 2017 |
|
Professor Tiago Outeiro
| α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B | 2017 |
|
Professor Tiago Outeiro
| A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death | 2016 |
|
Professor Tiago Outeiro
| A novel microfluidic cell co-culture platform for the study of the molecular mechanisms of Parkinson's disease and other synucleinopathies | 2016 |
|
Professor Tiago Outeiro
| Analysis of protein oligomeric species by sucrose gradients | 2016 |
|
Professor Tiago Outeiro
| C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease | 2016 |
|
Professor Tiago Outeiro
| Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin | 2016 |
|
Professor Tiago Outeiro
| Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity | 2016 |
|
Professor Tiago Outeiro
| Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease | 2016 |
|
Professor Tiago Outeiro
| Gene expression differences in peripheral blood of Parkinson's disease patients with distinct progression profiles | 2016 |
|
Professor Tiago Outeiro
| Glycation in Parkinson's disease and Alzheimer's disease | 2016 |
|
Professor Tiago Outeiro
| Glycation potentiates neurodegeneration in models of Huntington's disease | 2016 |
|
Professor Tiago Outeiro
| Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats | 2016 |
|
Professor Tiago Outeiro
| LRRK2 Promotes Tau Accumulation, Aggregation and Release | 2016 |
|
Professor Tiago Outeiro
| shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity | 2016 |
|
Professor Tiago Outeiro
| Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies | 2016 |
|
Professor Tiago Outeiro
| The caffeine-binding adenosine A 2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function | 2016 |
|
Professor Tiago Outeiro
| The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation | 2016 |
|
Professor Tiago Outeiro
| Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity | 2016 |
|
Professor Tiago Outeiro
| αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease | 2016 |
|
Professor Tiago Outeiro
| (Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy | 2015 |
|
Professor Tiago Outeiro
| Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium | 2015 |
|
Professor Tiago Outeiro
| Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells | 2015 |
|
Professor Tiago Outeiro
| Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism | 2015 |
|
Professor Tiago Outeiro
| Isostructural Re(i)/99mTc(I) tricarbonyl complexes for cancer theranostics | 2015 |
|
Professor Tiago Outeiro
| Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice | 2015 |
|
Professor Tiago Outeiro
| Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease | 2015 |
|
Professor Tiago Outeiro
| Mutant huntingtin alters Tau phosphorylation and subcellular distribution | 2015 |
|
Professor Tiago Outeiro
| Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo | 2015 |
|
Professor Tiago Outeiro
| Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour | 2015 |
|
Professor Tiago Outeiro
| Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cells | 2015 |
|
Professor Tiago Outeiro
| Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies | 2015 |
|
Professor Tiago Outeiro
| The Interplay between Alpha-Synuclein Clearance and Spreading | 2015 |
|
Professor Tiago Outeiro
| The sirtuin-2 inhibitor AK7 is neuroprotective in models of parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia | 2015 |
|
Professor Tiago Outeiro
| Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment | 2014 |
|
Professor Tiago Outeiro
| Challenges and promises in the development of neurotrophic factor-based therapies for parkinson's disease | 2014 |
|
Professor Tiago Outeiro
| Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease | 2014 |
|
Professor Tiago Outeiro
| DJ-1 interactions with a-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease | 2014 |
|
Professor Tiago Outeiro
| DJ-1 modulates aggregation and pathogenesis in models of huntington's disease | 2014 |
|
Professor Tiago Outeiro
| Integration of Single Cell Traps, Chemical Gradient Generator and Photosensors in a Microfluidic Platform for the Study of Alpha-Synuclein Toxicity in Yeast | 2014 |
|
Professor Tiago Outeiro
| Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions | 2014 |
|
Professor Tiago Outeiro
| Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells | 2014 |
|
Professor Tiago Outeiro
| MeCP2: A novel huntingtin interactor | 2014 |
|
Professor Tiago Outeiro
| Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator | 2014 |
|
Professor Tiago Outeiro
| Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease | 2014 |
|
Professor Tiago Outeiro
| Protein phosphorylation in neurodegeneration: Friend or foe? | 2014 |
|
Professor Tiago Outeiro
| Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation | 2014 |
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Professor Tiago Outeiro
| Studying the Molecular Determinants of Protein Oligomerization in Neurodegenerative Disorders by Bimolecular Fluorescence Complementation | 2014 |
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Professor Tiago Outeiro
| Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation | 2014 |
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Professor Tiago Outeiro
| The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity | 2014 |
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Professor Tiago Outeiro
| Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase | 2014 |
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Professor Tiago Outeiro
| α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner | 2014 |
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Professor Tiago Outeiro
| α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila | 2014 |
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Professor Tiago Outeiro
| Alpha-Synuclein and intracellular trafficking: Impact on the spreading of Parkinson's disease pathology | 2013 |
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Professor Tiago Outeiro
| Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy | 2013 |
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Professor Tiago Outeiro
| Epigenetics in Parkinson's and Alzheimer's diseases | 2013 |
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Professor Tiago Outeiro
| Harnessing the power of yeast to unravel the molecular basis of neurodegeneration | 2013 |
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Professor Tiago Outeiro
| Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications | 2013 |
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Professor Tiago Outeiro
| Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice | 2013 |
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Professor Tiago Outeiro
| Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease | 2013 |
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Professor Tiago Outeiro
| Limelight on alpha-synuclein: Pathological and mechanistic implications in neurodegeneration | 2013 |
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Professor Tiago Outeiro
| Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system | 2013 |
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Professor Tiago Outeiro
| LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models | 2013 |
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Professor Tiago Outeiro
| Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo | 2013 |
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Professor Tiago Outeiro
| Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: Implications for disease mechanisms and interventions in synucleinopathies | 2013 |
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Professor Tiago Outeiro
| Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells | 2013 |
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Professor Tiago Outeiro
| PLK2 modulates α-synuclein aggregation in yeast and mammalian cells | 2013 |
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Professor Tiago Outeiro
| SIRT1 and SIRT2: Emerging targets in neurodegeneration | 2013 |
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Professor Tiago Outeiro
| Structural basis of kynurenine 3-monooxygenase inhibition | 2013 |
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Professor Tiago Outeiro
| The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease | 2013 |
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Professor Tiago Outeiro
| The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation | 2013 |
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Professor Tiago Outeiro
| The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival | 2013 |
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Professor Tiago Outeiro
| β-defensin genomic copy number does not influence the age of onset in huntington’s disease | 2013 |
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Professor Tiago Outeiro
| β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons | 2013 |
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Professor Tiago Outeiro
| Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome | 2012 |
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Professor Tiago Outeiro
| Alpha-synuclein: From secretion to dysfunction and death | 2012 |
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Professor Tiago Outeiro
| Editorial on special topic: Sirtuins in metabolism, aging, and disease | 2012 |
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Professor Tiago Outeiro
| Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice | 2012 |
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Professor Tiago Outeiro
| Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation | 2012 |
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Professor Tiago Outeiro
| High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment | 2012 |
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Professor Tiago Outeiro
| Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation | 2012 |
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Professor Tiago Outeiro
| Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice | 2012 |
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Professor Tiago Outeiro
| SIRT2 as a therapeutic target for age-related disorders | 2012 |
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Professor Tiago Outeiro
| SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy | 2012 |
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Professor Tiago Outeiro
| Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context | 2012 |
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Professor Tiago Outeiro
| α-Synuclein modifies huntingtin aggregation in living cells | 2012 |
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