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Lookup NU author(s): Professor Tiago OuteiroORCiD
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© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.The budding yeast Saccharomyces cerevisiae has been extensively studied as a model organism for biochemical and genetic research for almost a century. In recent years, yeast has been successfully used to model many aspects of human diseases. These "humanized" yeast models have had a profound influence on our understanding of the molecular events underlying neurodegenerative disorders. Yeast models can recapitulate important molecular events that occur in neurodegeneration, and provide clues about the underpinnings of toxicity in animal models of disease. Moreover, yeast models have also served as a powerful tool for drug discovery. In this mini-review, we describe yeast models that have been used to study the molecular aspects of Parkinson's disease pathology and recent advances in the field based on these models.
Author(s): Amen T, Lázaro DF, Outeiro TF, Kaganovich D
Publication type: Review
Publication status: Published
Journal: Israel Journal of Chemistry
Online publication date: 24/11/2015
Acceptance date: 17/10/2015
ISSN (print): 0021-2148
ISSN (electronic): 1869-5868
Publisher: Wiley-VCH Verlag