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Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease

Lookup NU author(s): Professor Tiago OuteiroORCiD


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© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.The budding yeast Saccharomyces cerevisiae has been extensively studied as a model organism for biochemical and genetic research for almost a century. In recent years, yeast has been successfully used to model many aspects of human diseases. These "humanized" yeast models have had a profound influence on our understanding of the molecular events underlying neurodegenerative disorders. Yeast models can recapitulate important molecular events that occur in neurodegeneration, and provide clues about the underpinnings of toxicity in animal models of disease. Moreover, yeast models have also served as a powerful tool for drug discovery. In this mini-review, we describe yeast models that have been used to study the molecular aspects of Parkinson's disease pathology and recent advances in the field based on these models.

Publication metadata

Author(s): Amen T, Lázaro DF, Outeiro TF, Kaganovich D

Publication type: Review

Publication status: Published

Journal: Israel Journal of Chemistry

Year: 2015

Volume: 55

Issue: 11-12

Pages: 1252-1259

Online publication date: 24/11/2015

Acceptance date: 17/10/2015

ISSN (print): 0021-2148

ISSN (electronic): 1869-5868

Publisher: Wiley-VCH Verlag


DOI: 10.1002/ijch.201500071