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Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

Lookup NU author(s): Professor Tiago OuteiroORCiD


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© 2015 Elsevier Ltd. All rights reserved. Sirtuins are an evolutionarily conserved family of NAD+-dependent deacylases that display diversity in subcellular localization and function. SIRT2, the predominantly cytosolic sirtuin, is among the least understood of the seven mammalian sirtuin isoforms described (SIRT1-7). The purpose of this review is to summarize the most recent findings about the potential roles and effects of SIRT2 in mammalian metabolic homeostasis. We discuss the different functions and targets of SIRT2 in various physiological processes, including adipogenesis, fatty acid oxidation, gluconeogenesis, and insulin sensitivity. We also cover the role of SIRT2 in inflammation and oxidative stress due to the possible implications for metabolic disorders. Finally, we consider its potential as a therapeutic target for the prevention and treatment of type 2 diabetes.

Publication metadata

Author(s): Gomes P, Outeiro TF, Cavadas C

Publication type: Review

Publication status: Published

Journal: Trends in Pharmacological Sciences

Year: 2015

Volume: 36

Issue: 11

Pages: 756-768

Online publication date: 01/11/2015

Acceptance date: 01/01/1900

ISSN (print): 0165-6147

ISSN (electronic): 1873-3735

Publisher: Elsevier Ltd


DOI: 10.1016/

PubMed id: 26538315