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Lookup NU author(s): Professor Tiago OuteiroORCiD
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© 2015 Elsevier Ltd. All rights reserved. Sirtuins are an evolutionarily conserved family of NAD+-dependent deacylases that display diversity in subcellular localization and function. SIRT2, the predominantly cytosolic sirtuin, is among the least understood of the seven mammalian sirtuin isoforms described (SIRT1-7). The purpose of this review is to summarize the most recent findings about the potential roles and effects of SIRT2 in mammalian metabolic homeostasis. We discuss the different functions and targets of SIRT2 in various physiological processes, including adipogenesis, fatty acid oxidation, gluconeogenesis, and insulin sensitivity. We also cover the role of SIRT2 in inflammation and oxidative stress due to the possible implications for metabolic disorders. Finally, we consider its potential as a therapeutic target for the prevention and treatment of type 2 diabetes.
Author(s): Gomes P, Outeiro TF, Cavadas C
Publication type: Review
Publication status: Published
Journal: Trends in Pharmacological Sciences
Online publication date: 01/11/2015
Acceptance date: 01/01/1900
ISSN (print): 0165-6147
ISSN (electronic): 1873-3735
Publisher: Elsevier Ltd
PubMed id: 26538315