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Alpha-Synuclein and intracellular trafficking: Impact on the spreading of Parkinson's disease pathology

Lookup NU author(s): Professor Tiago OuteiroORCiD

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Abstract

Parkinson's disease is characterized by intracellular proteinaceous depositions known as Lewy bodies. These largely consist of the protein α-synuclein, whose physiological function remains unclear, but mutations and overexpression of the protein have been shown to cause early onset cases of Parkinson's disease. Deregulation of α-synuclein biology causes neurodegeneration and impaired neuronal trafficking, hinting at a possible contribution to the pathological mechanism. Recent studies produced some evidence hinting at the involvement of several regulators of the transport machinery such as Rab GTPases and SNARE proteins, but also shown that α-synuclein can be propagated between cells. Here, we discuss the molecular interplay of α-synuclein with the intracellular transport machinery, its consequences, and the implications for disease mechanisms. © 2013 Springer-Verlag Berlin Heidelberg.

Publication metadata

Author(s): Eisbach SE, Outeiro TF

Publication type: Review

Publication status: Published

Journal: Journal of Molecular Medicine

Year: 2013

Volume: 91

Issue: 6

Pages: 693-703

Print publication date: 01/06/2013

Online publication date: 25/04/2013

ISSN (print): 0946-2716

ISSN (electronic): 1432-1440

URL: https://doi.org/10.1007/s00109-013-1038-9

DOI: 10.1007/s00109-013-1038-9

PubMed id: 23616088

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