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The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival

Lookup NU author(s): Professor Tiago OuteiroORCiD

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Abstract

ATP13A2 is a lysosome-specific transmembrane ATPase protein of unknown function. This protein was initially linked to Kufor-Rakeb syndrome where it is absent or mutated. More recently, point mutations in ATP13A2 were linked to familial cases of Parkinson's disease.Zebrafish is commonly used as a vertebrate model for the study of different neurodegenerative diseases and has homologues of several Parkinson's disease associated proteins.Here, we describe for the first time the zebrafish homologue of human ATP13A2, demonstrating the homology between the protein sequences, which supports a conserved biological role. Furthermore, the spatial pattern of protein expression was studied and the lethality of the knockdown of ATP13A2 suggests it plays a crucial role during embryonic development. Our findings bring new insight into the biology of ATP13A2 and open novel opportunities for its study using zebrafish as a model organism. © 2012 Elsevier Inc.

Publication metadata

Author(s): Lopes da Fonseca T, Correia A, Hasselaar W, van der Linde HC, Willemsen R, Outeiro TF

Publication type: Article

Publication status: Published

Journal: Brain Research Bulletin

Year: 2013

Volume: 90

Issue: 1

Pages: 118-126

Print publication date: 01/01/2013

Online publication date: 31/10/2012

ISSN (print): 0361-9230

ISSN (electronic): 1873-2747

Publisher: Elsevier

URL: https://doi.org/10.1016/j.brainresbull.2012.09.017

DOI: 10.1016/j.brainresbull.2012.09.017

PubMed id: 23123961

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