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SIRT2 as a therapeutic target for age-related disorders

Lookup NU author(s): Professor Tiago OuteiroORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

Sirtuin proteins are conserved regulators of aging that have recently emerged as important modifiers of several diseases which commonly occur later in life such as cancer, diabetes, cardiovascular, and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function. SIRT1 has received much of attention due to its possible impact on longevity, while important biological and therapeutic roles of other sirtuins have been underestimated and just recently recognized. Here we focus on SIRT2, a member of the sirtuin family, and discuss its role in cellular and tissue-specific functions. This review summarizes the main scientific advances on SIRT2 protein biology and explores its potential as a therapeutic target for treatment of age-related disorders. © 2012 de Oliveira, Sarkander, Kazantsev and Outeiro.

Publication metadata

Author(s): de Oliveira RM, Sarkander J, Kazantsev AG, Outeiro TF

Publication type: Article

Publication status: Published

Journal: Frontiers in Pharmacology

Year: 2012

Volume: 3

Online publication date: 03/05/2012

Date deposited: 07/02/2019

ISSN (electronic): 1663-9812

Publisher: Frontiers Research Foundation

URL: https://doi.org/10.3389/fphar.2012.00082

DOI: 10.3389/fphar.2012.00082

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