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Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis

Lookup NU author(s): Professor Brian WalkerORCiD


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© 2017 The Author(s)Gas chromatography mass spectrometry has been the lynchpin of clinical assessment of steroid profiles for ∼3 decades. The improvements in assay performance offered by tandem mass spectrometry were assessed. Across the spectrum of glucocorticoid and androgen analytes tested, limits of detection and quantitation were ∼20 fold lower with triple than single quadrupole systems, but the more noticeable improvement was that signal to noise was substantially improved and the linear range wider. These benefits allowed more reliable and concomitant measurement of steroids with substantially different abundances and in smaller volumes of urine.

Publication metadata

Author(s): Homer N, Kothiya S, Rutter A, Walker BR, Andrew R

Publication type: Article

Publication status: Published

Journal: Analytical Biochemistry

Year: 2017

Volume: 538

Pages: 34-37

Online publication date: 06/09/2017

Acceptance date: 05/09/2017

Date deposited: 20/12/2017

ISSN (print): 0003-2697

ISSN (electronic): 1096-0309

Publisher: Academic Press Inc.


DOI: 10.1016/j.ab.2017.09.002

PubMed id: 28887174


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