Catherine Sykes
Professor Brian Walker
| 5α-Tetrahydrocorticosterone: a Topical Anti-inflammatory Glucocorticoid with an Improved Therapeutic Index in a Murine Model of Dermatitis | 2024 |
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Dr Elisa Villalobos Villegas
Professor Brian Walker
| ATP-binding cassette family C member 1 constrains metabolic responses to high-fat diet | 2024 |
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Dr Kerri Devine
Professor Brian Walker
| Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19 | 2024 |
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Professor Brian Walker
| Proof of concept for a superior therapeutic index of corticosterone compared with hydrocortisone in patients with congenital adrenal hyperplasia | 2024 |
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Professor Brian Walker
| 11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis | 2023 |
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Professor Brian Walker
| Contribution of local regeneration of glucocorticoids to tissue steroid pools | 2023 |
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Professor Brian Walker
| Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy | 2023 |
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Professor Brian Walker
| Memory deficits in juvenile rats with type 1 diabetes are due to excess 11β-HSD1 activity, up-regulated by high glucose concentration rather than insulin deficiency | 2023 |
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Professor Brian Walker
| Plasma cortisol linked gene networks in hepatic and adipose tissues implicate corticosteroid binding globulin in modulating tissue glucocorticoid action and cardiovascular risk | 2023 |
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Professor Brian Walker
| ABCC1 modulates negative feedback control of the hypothalamic-pituitary-adrenal axis in vivo in humans | 2022 |
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Professor Brian Walker
| Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5α-tetrahydrocorticosterone versus conventional glucocorticoids | 2022 |
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Professor Brian Walker
| Corticotroph isolation from Pomc-eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid-induced suppression of the Hypothalamus-Pituitary-Adrenal axis | 2022 |
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Professor Brian Walker
| Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-magnetic resonance spectroscopy | 2022 |
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Dr Elisa Villalobos Villegas
Professor Brian Walker
| The ATP-binding cassette proteins ABCC1 and ABCB1 as modulators of glucocorticoid action | 2022 |
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Dr Elisa Villalobos Villegas
Professor Brian Walker
| Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice | 2021 |
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Professor Brian Walker
| Effects of Obesity And Insulin on Tissue-Specific Recycling Between Cortisol And Cortisone in Men | 2021 |
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Professor Brian Walker
| Glucocorticoids associate with cardiometabolic risk factors in black South Africans | 2021 |
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Professor Brian Walker
| Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial | 2021 |
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Professor Brian Walker
| Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM) | 2021 |
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Professor Brian Walker
| Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease | 2021 |
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Professor Brian Walker
| Diet-induced weight loss alters hepatic glucocorticoid metabolism in type 2 diabetes mellitus | 2020 |
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Professor Brian Walker
| Estrogens and glucocorticoids in mammary adipose tissue: Relationships with body mass index and breast cancer features | 2020 |
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Professor Brian Walker
| Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood | 2020 |
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Professor Brian Walker
| GDF15 is elevated in conditions of glucocorticoid deficiency and is modulated by glucocorticoid replacement | 2020 |
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Professor Brian Walker
| Long-term stability of cortisol production and metabolism throughout adolescence: longitudinal twin study | 2020 |
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Professor Brian Walker
| Sexual dimorphism in cortisol metabolism throughout pubertal development: a longitudinal study | 2020 |
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Professor Brian Walker
| Androgens modulate glucocorticoid receptor activity in adipose 1 tissue and liver | 2019 |
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Professor Brian Walker
| Heritability of Cortisol Production and Metabolism Throughout Adolescence: A Twin Study | 2019 |
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Professor Brian Walker
| Higher Insulin Resistance & Adiposity in Post-menopausal Women With Breast Cancer Treated With Aromatase Inhibitors | 2019 |
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Professor Brian Walker
| Incidence of Type 2 diabetes mellitus in men receiving steroid 5α-reductase Inhibitors: a population-based cohort study | 2019 |
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Professor Brian Walker
| Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies | 2019 |
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Professor Brian Walker
| Neutrophil elastase-cleaved corticosteroid-binding globulin is absent in human plasma | 2019 |
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Professor Brian Walker
| Role of Hepatic Glucocorticoid Receptor 1 in metabolism in models 2 of 5αR1 deficiency in male mice | 2019 |
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Professor Brian Walker
| Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry | 2019 |
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Professor Brian Walker
| Dysregulation of cortisol metabolism in equine pituitary pars intermedia dysfunction | 2018 |
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Professor Brian Walker
| Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice | 2018 |
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Professor Brian Walker
| Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways | 2018 |
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Professor Brian Walker
| Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides | 2018 |
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Peng Yin
Professor Brian Walker
| Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study | 2018 |
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Professor Brian Walker
| Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study | 2018 |
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Professor Brian Walker
| 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI | 2017 |
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Professor Brian Walker
| Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans | 2017 |
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Professor Brian Walker
| Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct | 2017 |
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Professor Brian Walker
| Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity | 2017 |
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Professor Brian Walker
| Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis | 2017 |
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Professor Brian Walker
| Inhibition or deletion of 11β-HSD1 does not increase angiogenesis in ischemic retinopathy | 2017 |
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Professor Brian Walker
| Metabolic dysfunction in female mice with disruption of 5α-reductase 1 | 2017 |
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Professor Brian Walker
| Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models | 2017 |
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Professor Brian Walker
| Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™) | 2017 |
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Professor Brian Walker
| The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels | 2017 |
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Emeritus Professor Paul Burton
Professor Brian Walker
| Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits | 2017 |
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Professor Brian Walker
| 11β-hydroxysteroid dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice | 2016 |
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Professor Brian Walker
| ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy | 2016 |
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Professor Brian Walker
| Adrenal insufficiency in patients on long-term opioid analgesia | 2016 |
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Professor Brian Walker
| Aromatase inhibition reduces insulin sensitivity in healthy men | 2016 |
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Professor Brian Walker
| Cardiomyocyte and vascular smooth muscle-independent 11β-hydroxysteroid dehydrogenase 1 amplifies infarct expansion, hypertrophy, and the development of heart failure after myocardial infarction in male mice | 2016 |
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Professor Brian Walker
| Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery | 2016 |
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Professor Brian Walker
| Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry | 2016 |
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Professor Brian Walker
| Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness | 2016 |
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Professor Brian Walker
| Genome-wide associations for birth weight and correlations with adult disease | 2016 |
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Professor Brian Walker
| Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation | 2016 |
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Professor Brian Walker
| Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus | 2016 |
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Professor Brian Walker
| Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging | 2016 |
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Professor Brian Walker
| Systematic review and meta-analysis reveals acutely elevated plasma cortisol following fasting but not less severe calorie restriction | 2016 |
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Professor Brian Walker
| Vascular dysfunction in horses with endocrinopathic laminitis | 2016 |
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Professor Brian Walker
| 11β-hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men | 2015 |
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Professor Brian Walker
| 5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents | 2015 |
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Professor Brian Walker
| Cognitive and disease-modifying effects of 11β-hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer's disease | 2015 |
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Professor Brian Walker
| Convergence in insulin resistance between very severely obese and lean women at the end of pregnancy | 2015 |
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Professor Brian Walker
| Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women | 2015 |
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Professor Brian Walker
| Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): A randomised, double-blind, placebo-controlled trial | 2015 |
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Professor Brian Walker
| Efficacy of metformin in pregnant obese women: A randomised controlled trial | 2015 |
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Professor Brian Walker
| Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism | 2015 |
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Professor Brian Walker
| Generation and 3-dimensional quantitation of arterial lesions in mice using optical projection tomography | 2015 |
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Professor Brian Walker
| Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women | 2015 |
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Professor Brian Walker
| Health behaviours during pregnancy in women with very severe obesity | 2015 |
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Professor Brian Walker
| Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice | 2015 |
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Professor Brian Walker
| Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: Protocol for response-adaptive randomised placebo-controlled dosefinding parallel group trial (DexFEM) | 2015 |
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Professor Brian Walker
| Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice | 2015 |
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Professor Brian Walker
| Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry | 2015 |
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Professor Brian Walker
| 5α-Reductase Type 1 Modulates Insulin Sensitivity in Men | 2014 |
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Professor Brian Walker
| Activation of the hypothalamic-pituitary-adrenal axis in adults with mineralocorticoid receptor haploinsufficiency | 2014 |
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Professor Brian Walker
| Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist | 2014 |
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Professor Brian Walker
| Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with type 2 diabetes with and without fatty liver | 2014 |
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Professor Brian Walker
| Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia | 2014 |
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Professor Brian Walker
| Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin | 2014 |
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Professor Brian Walker
| Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning | 2014 |
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Professor Brian Walker
| Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE) | 2014 |
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Professor Brian Walker
| Relative adrenal insufficiency in mice deficient in 5α-reductase 1 | 2014 |
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Professor Brian Walker
| The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production | 2014 |
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Professor Brian Walker
| Tissue-specific dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls | 2014 |
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Professor Brian Walker
| Tissue-specific dysregulation of cortisol regeneration by 11βHSD1 in obesity: Has it promised too much? | 2014 |
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Professor Brian Walker
| Treatment and health outcomes in adults with congenital adrenal hyperplasia | 2014 |
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Professor Brian Walker
| Unhealthy lifestyle in early psychoses: The role of life stress and the hypothalamic-pituitary-adrenal axis | 2014 |
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Professor Brian Walker
Professor Andreas Schedl
| Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source | 2014 |
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Professor Brian Walker
| β-Cell-specific glucocorticoid reactivation attenuates inflammatory β-cell destruction | 2014 |
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