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Browsing publications by Professor Brian Walker.

Newcastle AuthorsTitleYearFull text
Professor Brian Walker
ABCC1 modulates negative feedback control of the hypothalamic-pituitary-adrenal axis in vivo in humans2022
Professor Brian Walker
Corticotroph isolation from Pomc-eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid-induced suppression of the Hypothalamus-Pituitary-Adrenal axis2022
Professor Brian Walker
Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice2021
Professor Brian Walker
Effects of Obesity And Insulin on Tissue-Specific Recycling Between Cortisol And Cortisone in Men2021
Professor Brian Walker
Glucocorticoids associate with cardiometabolic risk factors in black South Africans2021
Professor Brian Walker
Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial2021
Professor Brian Walker
Diet-induced weight loss alters hepatic glucocorticoid metabolism in type 2 diabetes mellitus2020
Professor Brian Walker
Estrogens and glucocorticoids in mammary adipose tissue: Relationships with body mass index and breast cancer features2020
Professor Brian Walker
Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood2020
Professor Brian Walker
GDF15 is elevated in conditions of glucocorticoid deficiency and is modulated by glucocorticoid replacement2020
Professor Brian Walker
Long-term stability of cortisol production and metabolism throughout adolescence: longitudinal twin study2020
Professor Brian Walker
Sexual dimorphism in cortisol metabolism throughout pubertal development: a longitudinal study2020
Professor Brian Walker
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease2020
Professor Brian Walker
Androgens modulate glucocorticoid receptor activity in adipose 1 tissue and liver2019
Professor Brian Walker
Heritability of Cortisol Production and Metabolism Throughout Adolescence: A Twin Study2019
Professor Brian Walker
Higher Insulin Resistance & Adiposity in Post-menopausal Women With Breast Cancer Treated With Aromatase Inhibitors2019
Professor Brian Walker
Incidence of Type 2 diabetes mellitus in men receiving steroid 5α-reductase Inhibitors: a population-based cohort study2019
Professor Brian Walker
Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies2019
Professor Brian Walker
Neutrophil elastase-cleaved corticosteroid-binding globulin is absent in human plasma2019
Professor Brian Walker
Role of Hepatic Glucocorticoid Receptor 1 in metabolism in models 2 of 5αR1 deficiency in male mice2019
Professor Brian Walker
Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry2019
Professor Brian Walker
Dysregulation of cortisol metabolism in equine pituitary pars intermedia dysfunction2018
Professor Brian Walker
Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice2018
Professor Brian Walker
Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways2018
Professor Brian Walker
Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides2018
Peng Yin
Professor Brian Walker
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study2018
Professor Brian Walker
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study2018
Professor Brian Walker
11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI2017
Professor Brian Walker
Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans2017
Professor Brian Walker
Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct2017
Professor Brian Walker
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity2017
Professor Brian Walker
Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis2017
Professor Brian Walker
Inhibition or deletion of 11β-HSD1 does not increase angiogenesis in ischemic retinopathy2017
Professor Brian Walker
Metabolic dysfunction in female mice with disruption of 5α-reductase 12017
Professor Brian Walker
Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models2017
Professor Brian Walker
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)2017
Professor Brian Walker
The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels2017
Professor Paul Burton
Professor Brian Walker
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits2017
Professor Brian Walker
11β-hydroxysteroid dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice2016
Professor Brian Walker
ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy2016
Professor Brian Walker
Adrenal insufficiency in patients on long-term opioid analgesia2016
Professor Brian Walker
Aromatase inhibition reduces insulin sensitivity in healthy men2016
Professor Brian Walker
Cardiomyocyte and vascular smooth muscle-independent 11β-hydroxysteroid dehydrogenase 1 amplifies infarct expansion, hypertrophy, and the development of heart failure after myocardial infarction in male mice2016
Professor Brian Walker
Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery2016
Professor Brian Walker
Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry2016
Professor Brian Walker
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness2016
Professor Brian Walker
Genome-wide associations for birth weight and correlations with adult disease2016
Professor Brian Walker
Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation2016
Professor Brian Walker
Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus2016
Professor Brian Walker
Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging2016
Professor Brian Walker
Systematic review and meta-analysis reveals acutely elevated plasma cortisol following fasting but not less severe calorie restriction2016
Professor Brian Walker
Vascular dysfunction in horses with endocrinopathic laminitis2016
Professor Brian Walker
11β-hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men2015
Professor Brian Walker
5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents2015
Professor Brian Walker
Cognitive and disease-modifying effects of 11β-hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer's disease2015
Professor Brian Walker
Convergence in insulin resistance between very severely obese and lean women at the end of pregnancy2015
Professor Brian Walker
Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women2015
Professor Brian Walker
Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): A randomised, double-blind, placebo-controlled trial2015
Professor Brian Walker
Efficacy of metformin in pregnant obese women: A randomised controlled trial2015
Professor Brian Walker
Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism2015
Professor Brian Walker
Generation and 3-dimensional quantitation of arterial lesions in mice using optical projection tomography2015
Professor Brian Walker
Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women2015
Professor Brian Walker
Health behaviours during pregnancy in women with very severe obesity2015
Professor Brian Walker
Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice2015
Professor Brian Walker
Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: Protocol for response-adaptive randomised placebo-controlled dosefinding parallel group trial (DexFEM)2015
Professor Brian Walker
Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice2015
Professor Brian Walker
Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry2015
Professor Brian Walker
5α-Reductase Type 1 Modulates Insulin Sensitivity in Men2014
Professor Brian Walker
Activation of the hypothalamic-pituitary-adrenal axis in adults with mineralocorticoid receptor haploinsufficiency2014
Professor Brian Walker
Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist2014
Professor Brian Walker
Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with type 2 diabetes with and without fatty liver2014
Professor Brian Walker
Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia2014
Professor Brian Walker
Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin2014
Professor Brian Walker
Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning2014
Professor Brian Walker
Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE)2014
Professor Brian Walker
Relative adrenal insufficiency in mice deficient in 5α-reductase 12014
Professor Brian Walker
The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production2014
Professor Brian Walker
Tissue-specific dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls2014
Professor Brian Walker
Tissue-specific dysregulation of cortisol regeneration by 11βHSD1 in obesity: Has it promised too much?2014
Professor Brian Walker
Treatment and health outcomes in adults with congenital adrenal hyperplasia2014
Professor Brian Walker
Unhealthy lifestyle in early psychoses: The role of life stress and the hypothalamic-pituitary-adrenal axis2014
Professor Brian Walker
Professor Andreas Schedl
Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source2014
Professor Brian Walker
β-Cell-specific glucocorticoid reactivation attenuates inflammatory β-cell destruction2014