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Ethical and safety issues of stem cell-based therapy

Lookup NU author(s): Professor Lyle Armstrong, Professor Majlinda LakoORCiD, Professor Miodrag Stojkovic



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© Ivyspring International Publisher. Results obtained from completed and on-going clinical studies indicate huge therapeutic potential of stem cell-based therapy in the treatment of degenerative, autoimmune and genetic disorders. However, clinical application of stem cells raises numerous ethical and safety concerns. In this review, we provide an overview of the most important ethical issues in stem cell therapy, as a contribution to the controversial debate about their clinical usage in regenerative and transplantation medicine. We describe ethical challenges regarding human embryonic stem cell (hESC) research, emphasizing that ethical dilemma involving the destruction of a human embryo is a major factor that may have limited the development of hESC-based clinical therapies. With previous derivation of induced pluripotent stem cells (iPSCs) this problem has been overcome, however current perspectives regarding clinical translation of iPSCs still remain. Unlimited differentiation potential of iPSCs which can be used in human reproductive cloning, as a risk for generation of genetically engineered human embryos and human-animal chimeras, is major ethical issue, while undesired differentiation and malignant transformation are major safety issues. Although clinical application of mesenchymal stem cells (MSCs) has shown beneficial effects in the therapy of autoimmune and chronic inflammatory diseases, the ability to promote tumor growth and metastasis and overestimated therapeutic potential of MSCs still provide concerns for the field of regenerative medicine. This review offers stem cell scientists, clinicians and patient’s useful information and could be used as a starting point for more in-depth analysis of ethical and safety issues related to clinical application of stem cells.

Publication metadata

Author(s): Volarevic V, Markovic BS, Gazdic M, Volarevic A, Jovicic N, Arsenijevic N, Armstrong L, Djonov V, Lako M, Stojkovic M

Publication type: Review

Publication status: Published

Journal: International Journal of Medical Sciences

Year: 2018

Volume: 15

Issue: 1

Pages: 36-45

Online publication date: 01/01/2018

Acceptance date: 11/10/2017

ISSN (print): 1449-1907

Publisher: Ivyspring International Publisher


DOI: 10.7150/ijms.21666