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Thrombotic microangiopathy and the kidney

Lookup NU author(s): Dr Vicky Brocklebank, Dr Katrina Wood, Professor David KavanaghORCiD

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Abstract

© 2018 by the American Society of Nephrology. Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI. It can be associated with significant morbidity and mortality, but a systematic approach to investigation and prompt initiation of supportive management and, in some cases, effective specific treatment can result in good outcomes. This review considers the classification, pathology, epidemiology, characteristics, and pathogenesis of the thrombotic microangiopathies, and outlines a pragmatic approach to diagnosis and management.

Publication metadata

Author(s): Brocklebank V, Wood KM, Kavanagh D

Publication type: Article

Publication status: Published

Journal: Clinical Journal of the American Society of Nephrology

Year: 2018

Volume: 13

Issue: 2

Pages: 300-317

Print publication date: 07/02/2018

Online publication date: 01/10/2017

Acceptance date: 29/09/2017

ISSN (print): 1555-9041

ISSN (electronic): 1555-905X

Publisher: American Society of Nephrology

URL: https://doi.org/10.2215/CJN.00620117

DOI: 10.2215/CJN.00620117

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