Amyloidosis

Attems, J; Thal, DR

doi:10.1016/B978-0-12-385157-4.00581-9

Amyloidosis

Lookup NU author(s): Professor Johannes Attems

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Abstract

© 2014 Elsevier Inc. All rights reserved. Amyloidosis refers to a heterogeneous group of disorders (systemic or localized) characterized by the extracellular deposition of insoluble fibrils in different tissues and organs leading to cellular damage and organ dysfunction. Twenty-four different proteins can form amyloid structures. In the human brain, the most frequent one is the amyloid-. β protein that is associated with Alzheimer's disease; other cerebral amyloidoses may be related to prions, cystatin C, transthyretin, gelsolin, ABri, and ADan. The main neuropathological lesions caused by cerebral amyloidosis are cerebral amyloid angiopathy and amyloid plaques.