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Methods for pathological classification of Alzheimer's disease

Lookup NU author(s): Professor Johannes Attems, Dr Kirsty McAleese, Dr Lauren WalkerORCiD


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© 2018, Springer Science+Business Media, LLC. The hallmark protein aggregates required for a neuropathological diagnosis of Alzheimer’s disease are intracellular neurofibrillary tangles and neuropil threads consisting of hyperphosphorylated tau, extracellular parenchymal amyloid β plaques, and neuritic plaques. In this chapter, we describe the neuropathological criteria for the neuropathological diagnosis of Alzheimer’s disease, as well as the fixation, processing, and histology protocols required for the assessment of post-mortem human brains.

Publication metadata

Author(s): Attems J, McAleese KE, Walker L

Editor(s): Robert Perneczky

Publication type: Book Chapter

Publication status: Published

Book Title: Biomarkers for Preclinical Alzheimer's Disease

Year: 2018

Volume: 137

Pages: 71-89

Online publication date: 24/02/2018

Acceptance date: 02/04/2016

Series Title: Neuromethods

Publisher: Humana Press

Place Published: New York, NY, USA


DOI: 10.1007/978-1-4939-7674-4_5

Library holdings: Search Newcastle University Library for this item

ISBN: 9781493976737