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Lookup NU author(s): Professor Johannes Attems, Dr Kirsty McAleese, Dr Lauren WalkerORCiD
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© 2018, Springer Science+Business Media, LLC. The hallmark protein aggregates required for a neuropathological diagnosis of Alzheimer’s disease are intracellular neurofibrillary tangles and neuropil threads consisting of hyperphosphorylated tau, extracellular parenchymal amyloid β plaques, and neuritic plaques. In this chapter, we describe the neuropathological criteria for the neuropathological diagnosis of Alzheimer’s disease, as well as the fixation, processing, and histology protocols required for the assessment of post-mortem human brains.
Author(s): Attems J, McAleese KE, Walker L
Editor(s): Robert Perneczky
Publication type: Book Chapter
Publication status: Published
Book Title: Biomarkers for Preclinical Alzheimer's Disease
Year: 2018
Volume: 137
Pages: 71-89
Online publication date: 24/02/2018
Acceptance date: 02/04/2016
Series Title: Neuromethods
Publisher: Humana Press
Place Published: New York, NY, USA
URL: https://doi.org/10.1007/978-1-4939-7674-4_5
DOI: 10.1007/978-1-4939-7674-4_5
Library holdings: Search Newcastle University Library for this item
ISBN: 9781493976737
