Toggle Main Menu Toggle Search

Open Access padlockePrints

Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and aid to differential diagnosis

Lookup NU author(s): Myrto Stylianou, Dr Nik Murphy, Dr Luis Peraza RodriguezORCiD, Dr Sara Graziadio, Dr Ruth Cromarty, Dr Alison Killen, Professor John O'Brien, Professor Alan ThomasORCiD, Dr Fiona LeBeau, Professor John-Paul TaylorORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Objective: We investigated for quantitative EEG (QEEG) differences between Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) patients and healthy controls, and for QEEG signatures of cognitive fluctuations (CFs) in DLB.Methods: We analyzed eyes-closed, resting state EEGs from 18 AD, 17 DLB and 17 PDD patients with mild dementia, and 21 age-matched controls. Measures included spectral power, dominant frequency (DF), frequency prevalence (FP), and temporal DF variability (DFV), within defined EEG frequency bands and cortical regions.Results: DLB and PDD patients showed a leftward shift in the power spectrum and DF. AD patients showed greater DFV compared to the other groups. In DLB patients only, greater DFV and EEG slowing were correlated with CFs, measured by the clinician assessment of fluctuations (CAF) scale. The diagnostic accuracy of the QEEG measures was 94% (90.4% - 97.9%), with 92.26% (80.4% – 100%) sensitivity and 83.3% (73.6% - 93%) specificity.Conclusion: Although greater DFV was only shown in the AD group, within the DLB group a positive DFV - CF correlation was found. QEEG measures could classify DLB and AD patients with high sensitivity and specificity.Significance: The findings add to building literature suggesting that EEG is a viable diagnostic and symptom biomarker in dementia, particularly DLB.

Publication metadata

Author(s): Stylianou M, Murphy N, Peraza LR, Graziadio S, Cromarty R, Killen A, O'Brien JT, Thomas AJ, LeBeau FEN, Taylor J-P

Publication type: Article

Publication status: Published

Journal: Clinical Neurophysiology

Year: 2018

Volume: 129

Issue: 6

Pages: 1209-1220

Print publication date: 01/06/2018

Online publication date: 03/04/2018

Acceptance date: 10/03/2018

Date deposited: 03/04/2018

ISSN (print): 1388-2457

ISSN (electronic): 1872-8952

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.clinph.2018.03.013


Altmetrics provided by Altmetric


Funder referenceFunder name
Alzheimer’s Research UK