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Role of neuroinflammation in Alzheimer’s trajectory and in vivo quantification using PET

Lookup NU author(s): Professor David BrooksORCiD



This is the authors' accepted manuscript of a review published in its final definitive form in 2018. For re-use rights please refer to the publishers terms and conditions.


Recent evidence suggests that neuroinflammation and immunity play a significant role in Alzheimer’s disease (AD) and other neurodegenerative diseases. It has also been observed that, independent of the presence of aggregated proteins, neuroinflammation could be present in different neurodegenerative diseases. It has also been suggested that neuroinflammation could occur well ahead of amyloid deposition in AD. Recent genetic studies and other preclinical studies specifically point to a role of neuroinflammation and, in this review, we evaluate the evidence of neuroinflammation in the Alzheimer’s disease trajectory and the different imaging modalities by which we could monitor neuroinflammation in vivo in humans.

Publication metadata

Author(s): Edison P, Brooks DJ

Publication type: Review

Publication status: Published

Journal: Journal of Alzheimer's Disease

Year: 2018

Volume: 64

Issue: s1

Pages: S339-S351

Print publication date: 12/06/2018

Online publication date: 26/05/2018

Acceptance date: 05/02/2018

ISSN (print): 1387-2877

ISSN (electronic): 1875-8908


DOI: 10.3233/JAD-179929