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Opto‐electro‐thermal optimization of photonic probes for optogenetic neural stimulation

Lookup NU author(s): Dr Rolando Berlinguer PalminiORCiD, Dr Nilhil Ponon, Professor Anthony O'Neill, Professor Patrick Degenaar



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Implantable photonic probes are of increasing interest to the field of biophotonics and in particular, optogenetic neural stimulation. Active probes with onboard light emissive elements allow for electronic multiplexing and can be manufactured through existing microelectronics methods. However, as the optogenetics field moves towards clinical practice, an important question arises as to whether such probes will cause excessive thermal heating of the surrounding tissue. Light emitting diodes typically produce more heat than light. The resultant temperature rise of the probe surface therefore needs to be maintained under the regulatory limit of 2O C. This work combines optical and thermal modelling which have been experimental verified. Analysis has been performed on the effect of probe/emitter geometries, emitter, and radiance requirements. Finally, the effective illumination volume has been calculated within thermal limits for different probe emitter types and required thresholds

Publication metadata

Author(s): Dong N, Berlinguer-Palmini R, Soltan A, Ponon N, O'Neil A, Travelyan A, Maaskant P, Degenaar P, Sun X

Publication type: Article

Publication status: Published

Journal: Journal of Biophotonics

Year: 2018

Volume: 11

Issue: 10

Print publication date: 01/10/2018

Online publication date: 30/03/2018

Acceptance date: 12/03/2018

Date deposited: 23/03/2018

ISSN (print): 1864-063X

ISSN (electronic): 1864-0648

Publisher: Wiley - V C H Verlag GmbH & Co. KGaA


DOI: 10.1002/jbio.201700358

PubMed id: 29603666


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Funder referenceFunder name
102037/ Z/13/Z