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Buckwheat and CVD Risk Markers: A Systematic Review and Meta-Analysis

Lookup NU author(s): Liangkui Li, Professor Georg Lietz, Emeritus Professor Chris SealORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


The effects of buckwheat intake on cardiovascular diseases (CVDs) have not been systematically investigated. The aim of the present study was to comprehensively summarize studies in humans and animals, evaluating the impact of buckwheat consumption on CVD risk markers and to conduct a meta-analysis of relevant data. Thirteen randomized, controlled human studies, two cross-sectional human studies and twenty-one animal studies were identified. Using random-effects models, the weighted mean difference of post-intervention concentrations of blood glucose, total cholesterol and triglycerides were significantly decreased following buckwheat intervention compared with controls [differences in blood glucose: -0.85 mmol/L (95% CI: -1.31, -0.39), total cholesterol: 0.50 mmol/L (95% CI: -0.80, -0.20) and triglycerides: 0.25 mmol/L (95% CI: -0.49, -0.02)]. Responses of a similar magnitude were seen in two cross-sectional studies. For animal studies, nineteen of twenty-one studies showed a significant reduction in total cholesterol of between 12% and 54%, and fourteen of twenty studies showed a significant reduction in triglycerides of between 2% and 74%. All exhibited high unexplained heterogeneity. There was inconsistency in HDL cholesterol outcomes in both human and animal studies. It remains unclear whether increased buckwheat intake significantly benefits other markers of CVD risk, such as weight, blood pressure, insulin, and LDL-cholesterol, and underlying mechanisms responsible for any effects are unclear.

Publication metadata

Author(s): LI L, Lietz G, Seal C

Publication type: Article

Publication status: Published

Journal: Nutrients

Year: 2018

Volume: 10

Issue: 5

Online publication date: 15/05/2018

Acceptance date: 10/05/2018

Date deposited: 15/05/2018

ISSN (electronic): 2072-6643

Publisher: MDPI AG


DOI: 10.3390/nu10050619


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