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Lookup NU author(s): Dr Simon Wilkinson
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© 2017 Elsevier B.V. In the present study, three laboratories independently compared percutaneous absorption and distribution of 4-n-butylresorcinol, using human skin from five donors. Each laboratory used the same protocol for percutaneous absorption studies but different LC–MS/MS analytical methods to quantify the test compound. All laboratories respected the mass balance criteria (i.e. 100 ± 15%; average 96.5–102% of applied dose). Regarding usual inter-lab variability, good agreement was observed for all compartments with the greatest difference in the epidermis: 3.3 fold increase. The data obtained demonstrate that robustness of skin absorption data rely on properly validated analytical methods including sample extraction and LC–MS/MS method. It also includes clearly defined cutaneous absorption protocol for dose skin preparation, application, washing and tape stripping.
Author(s): Wargniez W, Jungman E, Wilkinson S, Seyler N, Gregoire S
Publication type: Article
Publication status: Published
Journal: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Print publication date: 15/08/2017
Online publication date: 26/05/2017
Acceptance date: 25/05/2017
ISSN (print): 1570-0232
ISSN (electronic): 1873-376X
Publisher: Elsevier BV
PubMed id: 28675855
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