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Drug-Induced Liver Disease

Lookup NU author(s): Professor Ann DalyORCiD


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© 2017 Elsevier Ltd. All rights reserved. Drug-induced liver disease or drug-induced liver injury (DILI) is a rare but serious complication of drug treatment. DILI may be concentration-dependent; an example is potentially fatal liver failure from acetaminophen overdose. However, some commonly prescribed drugs, especially antimicrobials, may cause idiosyncratic DILI when used at the recommended dose. The underlying mechanism for idiosyncratic DILI is poorly understood. Methods to determine potential for new drugs to cause idiosyncratic DILI during development exist but need improvement. Risk factors for idiosyncratic DILI include age, gender, drug-drug interactions, and genetics. Studies to predict individual susceptibility to idiosyncratic DILI are in progress.

Publication metadata

Author(s): Daly AK

Publication type: Book Chapter

Publication status: Published

Book Title: Comprehensive Medicinal Chemistry III

Year: 2017

Volume: 4-8

Pages: 205-216

Online publication date: 13/06/2017

Acceptance date: 02/04/2016

Publisher: Elsevier Inc.


DOI: 10.1016/B978-0-12-409547-2.12382-0

Library holdings: Search Newcastle University Library for this item

ISBN: 9780128032008