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The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease

Lookup NU author(s): Professor David BrooksORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. AD pathology is characterized by abnormal aggregation of the proteins amyloid-b (Ab) and hyper-phosphorylated tau. No effective disease modifying therapies are currently available. A short-duration intervention with 40 Hz light flicker has been shown to reduce brain Ab load in transgenic mice. We aimed to test the effect of a similar short-duration 40 Hz light flicker regime in human AD patients. We utilized a Light Emitting Diode (LED) light bulb with a 40 Hz flicker. Six Ab positive patients, received 10 days of light therapy, 2 hours of daily exposure, and underwent a post-intervention PiB PET on day 11. After 10 days of light therapy, no significant decrease of PiB SUVR values were detected in any volumes of interest tested (primary visual cortex, visual association cortex, lateral parietal cortex, precuneus, posterior cingulate) or in the total motor cortex, and longer treatments may be necessary to induce amyloid removal in humans.

Publication metadata

Author(s): Ismail R, Hansen AK, Parbo P, Brændgaard H, Gottrup H, Brooks DJ, Borghammer P

Publication type: Article

Publication status: Published

Journal: International Journal of Alzheimer's Disease

Year: 2018

Volume: 2018

Online publication date: 30/07/2018

Acceptance date: 25/06/2018

Date deposited: 28/06/2018

ISSN (print): 2090-8024

ISSN (electronic): 2090-0252

Publisher: Hindawi Publishing


DOI: 10.1155/2018/6852303


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Funder referenceFunder name
Department of Nuclear Medicine & PET Centre
Lundbeck Foundation