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HLA-A∗33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors

Lookup NU author(s): Professor Ann Daly

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Abstract

© 2018 American Chemical Society. The HLA class I allele HLA-A∗33:03 is a risk factor for ticlopidine-induced liver injury. Herein, we show HLA class I-restricted ticlopidine-specific CD8+ T-cell activation in healthy donors expressing HLA-A∗33:03. Cloned CD8+ T-cells proliferated and secreted IFN-γ in the presence of ticlopidine and autologous antigen presenting cells. A reduction of the T-cell response after blocking with HLA-class I and HLA-A∗33 antibodies indicates that the interaction between drugs and the HLA allele detected in genetic association studies may be important for T-cell activation.


Publication metadata

Author(s): Usui T, Tailor A, Faulkner L, Meng X, Farrell J, Daly AK, Dear GJ, Park BK, Naisbitt DJ

Publication type: Article

Publication status: Published

Journal: Chemical Research in Toxicology

Year: 2018

Volume: 31

Issue: 10

Pages: 1022-1024

Print publication date: 15/10/2018

Online publication date: 04/09/2018

Acceptance date: 02/04/2018

ISSN (print): 0893-228X

ISSN (electronic): 1520-5010

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acs.chemrestox.8b00163

DOI: 10.1021/acs.chemrestox.8b00163


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