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Mitochondria and cellular senescence: Implications for musculoskeletal ageing

Lookup NU author(s): Leena Habiballa, Hanna Salmonowicz, Dr Joao Passos

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Abstract

© 2018 Elsevier Inc. Musculoskeletal ageing and its associated diseases are major contributors to the loss of independence and reduced quality of life in older people. Several recent studies indicate that cellular senescence is a contributor to age-related loss of function in various organs including muscle, bones and joints. Importantly, these studies indicate that therapies targeting specifically senescent cells have great therapeutic potential in improving musculoskeletal health during ageing. Senescent cells are characterised by dramatic changes in mitochondrial function, metabolism and homeostasis. Mitochondrial dysfunction has been shown to contribute to senescence and the SASP. Here we review the role of cellular senescence in musculoskeletal ageing as well as the potential mechanisms by which mitochondrial dysfunction may impact on the induction and development of the senescent phenotype.


Publication metadata

Author(s): Habiballa L, Salmonowicz H, Passos JF

Publication type: Article

Publication status: Published

Journal: Free Radical Biology and Medicine

Year: 2019

Volume: 132

Pages: 3-10

Print publication date: 20/02/2019

Online publication date: 15/10/2018

Acceptance date: 09/10/2018

ISSN (print): 0891-5849

ISSN (electronic): 1873-4596

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.freeradbiomed.2018.10.417

DOI: 10.1016/j.freeradbiomed.2018.10.417


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