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Reactive Oxygen Species Detection in Senescent Cells

Lookup NU author(s): Stella Victorelli, Dr Joao Passos


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Cumulative evidence suggests that cellular senescence plays a variety of important physiological roles, including tumor suppression, embryonic development and ageing. Senescent cells are characterized by increased production of reactive oxygen species (ROS), mostly produced by dysfunctional mitochondria. Both intracellular and extracellular ROS have been shown to contribute to the induction of senescence. ROS have also been shown to act as signaling molecules during senescence, stabilizing the cell-cycle arrest. In this chapter, we present a detailed description of protocols that allow us to characterize intracellular and extracellular ROS in live senescent cells.

Publication metadata

Author(s): Victorelli S, Passos JF

Editor(s): Marco Demaria

Publication type: Book Chapter

Publication status: Published

Book Title: Cellular Senescence: Methods and Protocols

Year: 2019

Volume: 1896

Pages: 21-29

Acceptance date: 02/04/2018

Series Title: Methods in Molecular Biology

Publisher: Humana Press

Place Published: New York


DOI: 10.1007/978-1-4939-8931-7_3

PubMed id: 30474836

Library holdings: Search Newcastle University Library for this item

ISBN: 9781493989300