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Supervised walking improves cardiorespiratory fitness, exercise tolerance, and fatigue in women with primary Sjögren’s syndrome: a randomized-controlled trial

Lookup NU author(s): Professor Fai Ng, Dr Dennis Lendrem, Professor Michael Trenell

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Springer Verlag, 2019.

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Abstract

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Objective: The aim of this study was to evaluate the safety and effectiveness of a supervised walking program in women with primary Sjögren’s syndrome (pSS). Methods: Forty-five sedentary women fulfilling the American European Consensus Criteria for pSS were randomized to a training group (TG, n = 23) or control group (CG, n = 22). Patients in the TG were submitted to supervise walking three times a week for 16 weeks. The patients of the CG were instructed to not perform any kind of regular physical exercise. Physical fitness [maximum oxygen uptake (VO2max) and distance], EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI), hematological tests, and Medical Outcomes Study 36 (SF-36) were assessed at baseline and week 16. In addition, EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI), Functional Assessment of Chronic Illness Therapy Fatigue Subscale (FACIT-fatigue), and Beck Depression Inventory (BDI) were measured prior to intervention, after 8 and 16 weeks. Patient global assessment of response to therapy was completed at the final assessment. An intent-to-treat analysis was performed. Results: After 16 weeks, the mean change of VO2max (ml/kg/min), distance, and FACIT-fatigue were higher in the TG than in the CG (p = 0.016, p = 0.043 and p = 0.030, respectively). Improved cardiorespiratory fitness was associated with improvements in fatigue scores and physical components of quality of life (SF-36). Furthermore, improved fatigue scores were associated with reduced depression and improvements in the physical and mental components of SF-36. Overall, 95.4% of patients in the TG rated themselves as clinically improved versus 62% of the patients in the CG (p = 0.049). There was no flare in disease activity and no serious adverse events with exercise. Conclusions: This supervised walking program was demonstrated to be feasible and safe with improvements in cardiorespiratory fitness, exercise tolerance, fatigue, and patient perception of improvement in pSS patients. Trial registration: Clinical Trials.gov ID, number NCT02370225.


Publication metadata

Author(s): Miyamoto ST, Valim V, Carletti L, Ng W-F, Perez AJ, Lendrem DW, Trennel M, Giovelli RA, Dias LH, Serrano EV, Subtil AM, Abreu VC, Natour J

Publication type: Article

Publication status: Published

Journal: Rheumatology International

Year: 2019

Volume: 39

Issue: 2

Pages: 227-238

Print publication date: 01/02/2019

Online publication date: 02/01/2019

Acceptance date: 24/11/2018

Date deposited: 03/06/2019

ISSN (print): 0172-8172

ISSN (electronic): 1437-160X

Publisher: Springer Verlag

URL: https://doi.org/10.1007/s00296-018-4213-z

DOI: 10.1007/s00296-018-4213-z


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