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Mitochondrial quality control as a key determinant of cell survival

Lookup NU author(s): Lucy Sedlackova, Dr Viktor Korolchuk

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Abstract

© 2019 Elsevier B.V. Mitochondria are the energy producing dynamic double-membraned organelles essential for cellular and organismal survival. A multitude of intra- and extra-cellular signals involved in the regulation of energy metabolism and cell fate determination converge on mitochondria to promote or prevent cell survival by modulating mitochondrial function and structure. Mitochondrial fitness is maintained by mitophagy, a pathway of selective degradation of dysfunctional organelles. Mitophagy impairment and altered clearance results in increased levels of dysfunctional and structurally aberrant mitochondria, changes in energy production, loss of responsiveness to intra- and extra-cellular signals and ultimately cell death. The decline of mitochondrial function and homeostasis with age is reported to be central to age-related pathologies. Here we discuss the molecular mechanisms controlling mitochondrial dynamics, mitophagy and cell death signalling and how their perturbation may contribute to ageing and age-related illness.

Publication metadata

Author(s): Sedlackova L, Korolchuk VI

Publication type: Review

Publication status: Published

Journal: Biochimica et Biophysica Acta - Molecular Cell Research

Year: 2019

Volume: 1866

Issue: 4

Pages: 575-587

Print publication date: 01/04/2019

Online publication date: 28/12/2018

Acceptance date: 21/12/2018

ISSN (print): 0167-4889

ISSN (electronic): 1879-2596

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.bbamcr.2018.12.012

DOI: 10.1016/j.bbamcr.2018.12.012

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