Publications by Professor Viktor Korolchuk - ePrints

Browsing publications by Professor Viktor Korolchuk.

Newcastle Authors	Title	Year
Niall Wilson Professor Viktor Korolchuk	Autophagy, aging, and age-related neurodegeneration	2024
Professor Viktor Korolchuk	Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling	2024
Dr Tetsushi Kataura Niall Wilson Gailing Ma Professor Viktor Korolchuk	Mitophagy as a guardian against cellular aging	2024
Dr Rozaliya Tsikandelova Eldo Galo Edvinas Cerniauskas Dr Dean Hallam Dr Maria Georgiou et al.	Retinal cells derived from patients with DRAM2-dependent CORD21 dystrophy exhibit key lysosomal enzyme deficiency and lysosomal content accumulation	2024
Dr Tetsushi Kataura Professor Viktor Korolchuk	Ruthenium complex containing 1,3-thiazolidine-2-thione inhibits hepatic cancer stem cells by suppressing Akt/mTOR signalling and leading to apoptotic and autophagic cell death	2024
George Kelly Dr Tetsushi Kataura Dr Johan Panek Hanna Salmonowicz Hannah Kendall et al.	Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule	2024
Dr Tetsushi Kataura Lucy Sedlackova Niall Wilson Dr Satomi Miwa Dr Daniel Erskine et al.	Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models	2024
Dr Tetsushi Kataura Professor Viktor Korolchuk	Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons	2023
Hanna Salmonowicz Dr James Chapman George Kelly Professor Laura Greaves Professor Derek Mann et al.	Apoptotic stress causes mtDNA release during senescence and drives the SASP	2023
Lucy Sedlackova Dr Tetsushi Kataura Professor Viktor Korolchuk	Metabolic function of autophagy is essential for cell survival	2023
Lucy Sedlackova Dr Tetsushi Kataura Gisela Otten Professor Viktor Korolchuk	NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency	2023
Professor Viktor Korolchuk	Preface	2023
Professor Viktor Korolchuk	Preface	2023
Niall Wilson Dr Tetsushi Kataura Professor Viktor Korolchuk	The autophagy–NAD axis in longevity and disease	2023
Joshua Ratliffe Dr Tetsushi Kataura Gisela Otten Professor Viktor Korolchuk	The evolution of selective autophagy as a mechanism of oxidative stress response: The evolutionarily acquired ability of selective autophagy receptors to respond to oxidative stress is beneficial for human longevity	2023
Dr Maria Georgiou Dr Chunbo Yang Rob Atkinson Dr Adriana Buskin Dr Joseph Collin et al.	Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient iPSC-derived retinal pigment epithelium cells	2022
Dr Tetsushi Kataura Lucy Sedlackova Gisela Otten David Shapira Dr Filippo Scialo et al.	Autophagy promotes cell survival by maintaining NAD levels	2022
Chanachai Sae-Lee Dr Timothy Barrow Dr Yoana Rabanal Ruiz Daniel Green Professor Viktor Korolchuk et al.	Genomic targets and selective inhibition of DNA methyltransferase isoforms	2022
Dr Tetsushi Kataura Gisela Otten Dr Yoana Rabanal Ruiz Francesca Urselli Dr Filippo Scialo et al.	NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy	2022
Dr Tetsushi Kataura Professor Viktor Korolchuk	Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2	2022
Dr Marzena Kurzawa-Akanbi Dr Florence Burte Dr Birthe Hilgen Dr Rachel Queen Dr Jonathan Coxhead et al.	Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina	2022
Dr Ed Fielder Dr Tengfei Wan Ghazaleh Alimohammadiha Abbas Ishaq Evon Low et al.	Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice	2022
Dr Jack Leslie Dr Hannah Paish Amy Collins Rebecca Scott Abi Watson et al.	A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis	2021
Marti Cadena Sandoval Dr Bernadette Carroll Professor Viktor Korolchuk	G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling	2021
Dr Tengfei Wan Mary Johnson Professor Viktor Korolchuk Dr Gabriele Saretzki	Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy	2021
Dr Daniel Erskine Dr David Koss Professor Viktor Korolchuk Professor Tiago Outeiro Professor Johannes Attems et al.	Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders	2021
Dr Yoana Rabanal Ruiz Lucy Sedlackova Dr Glyn Nelson Dr Bernadette Carroll Professor Viktor Korolchuk et al.	mTORC1 activity is supported by spatial association with focal adhesions	2021
Professor Viktor Korolchuk	Ochratoxin A induces NLRP3 inflammasome-mediated pyroptosis via activation of ROS modulated by autophagy in vitro	2021
Professor Viktor Korolchuk	Autophagy in Neurodegenerative Diseases	2020
Edvinas Cerniauskas Dr Marzena Kurzawa-Akanbi Dr Long Xie Dr Dean Hallam Marina Moya Molina et al.	Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function	2020
Professor Viktor Korolchuk	Redox signalling in physiology, ageing and disease	2020
Lucy Sedlackova Professor Viktor Korolchuk	The crosstalk of NAD, ROS and autophagy in cellular health and ageing	2020
Lucy Sedlackova George Kelly Professor Viktor Korolchuk	The pROS of Autophagy in Neuronal Health	2020
Lucy Sedlackova Professor Viktor Korolchuk	Mitochondrial quality control as a key determinant of cell survival	2019
Professor Viktor Korolchuk Dr Bernadette Carroll	PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis	2019
Professor Viktor Korolchuk	Preface	2019
Clara Correia Melo Dr Jodie Birch Dr Ed Fielder Dr James Chapman Dr Anthony Lagnado et al.	Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice	2019
Dr Olena Kucheryavenko Dr Glyn Nelson Professor Thomas von Zglinicki Professor Viktor Korolchuk Dr Bernadette Carroll et al.	The mTORC1-autophagy pathway is a target for senescent cell elimination	2019
Professor Viktor Korolchuk	Autophagy: 'Self-Eating' Your Way to Longevity	2018
Dr Yoana Rabanal Ruiz Professor Viktor Korolchuk	mTORC1 and nutrient homeostasis: The central role of the lysosome	2018
Dr Bernadette Carroll Professor Viktor Korolchuk	Nutrient sensing, growth and senescence	2018
Dr Bernadette Carroll Diego Manni Dr Rhoda Stefanatos Fiona Menzies Dr Graham Smith et al.	Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis	2018
Professor Robin Harris Professor Viktor Korolchuk	Preface	2018
Dr Yoshiki Hase Dr Aiqing Chen Dr Lucinda Craggs Yumi Yamamoto Lizzie Gemmell et al.	Severe white matter astrocytopathy in CADASIL	2018
Professor Viktor Korolchuk Dr Kehe Huang Dr XingXiang Chen	Taurine attenuates OTA-promoted PCV2 replication through blocking ROS-dependent autophagy via inhibiting AMPK/mTOR signaling pathway	2018
Dr Dean Hallam Dr Joseph Collin Dr Sanja Bojic Dr Valeria Chichagova Dr Adriana Buskin et al.	An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure	2017
Dr Bernadette Carroll Professor Viktor Korolchuk	Dysregulation of mTORC1/autophagy axis in senescence	2017
Professor Viktor Korolchuk Dr Satomi Miwa Dr Bernadette Carroll Professor Thomas von Zglinicki	Mitochondria in cell senescence: Is mitophagy the weakest link?	2017
Dr Yoana Rabanal Ruiz Gisela Otten Professor Viktor Korolchuk	mTORC1 as the main gateway to autophagy	2017
Dr Bernadette Carroll Dr Glyn Nelson Dr Yoana Rabanal Ruiz Dr Olena Kucheryavenko Professor Penny Lovat et al.	Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing	2017
Professor Viktor Korolchuk	Selenomethionine Alleviates AFB1-Induced Damage in Primary Chicken Hepatocytes by Inhibiting CYP450 1A5 Expression via Upregulated SelW Expression	2017
Professor Viktor Korolchuk Dr James Murray	Signalling mechanisms in autophagy: An introduction to the issue	2017
Dr Nuria Martinez Lopez Gisela Otten Dr Bernadette Carroll Professor Rajat Singh Professor Viktor Korolchuk et al.	Autophagy, lipophagy and lysosomal lipid storage disorders	2016
Dr Bernadette Carroll Gisela Otten Matthew Ratcliff Dr Graham Smith Dr Joao Passos et al.	Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity	2016
Professor Viktor Korolchuk Dr Bernadette Carroll Professor Penny Lovat Dr Nuria Martinez Lopez	Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Ed.)	2016
Dr Clara Correia Melo Francisco Marques Rhys Anderson Dr Graeme Hewitt Dr Bernadette Carroll et al.	Mitochondria are required for pro-ageing features of the senescent phenotype	2016
Gisela Otten Diego Manni Professor Viktor Korolchuk	Mitochondrial degradation, autophagy and neurodegenerative disease	2016
Diego Manni Professor Viktor Korolchuk	Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure	2016
Gisela Otten Professor Viktor Korolchuk	PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder	2016
Dr Graeme Hewitt Professor Viktor Korolchuk	Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance	2016
Dr Graeme Hewitt Dr Bernadette Carroll Dr Clara Correia Melo Mikolaj Ogrodnik Dr Glyn Nelson et al.	SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair	2016
Dr Bernadette Carroll Dr Long Xie Professor Penny Lovat Professor Viktor Korolchuk	Targeting the persistent activation of mammalian target of rapamycin in BRAF mutated melanoma as a novel therapeutic strategy	2016
Professor Viktor Korolchuk Dr Bernadette Carroll Dr Long Xie Carola Dostal Professor Penny Lovat et al.	Targeting the persistent activation of mTOR in B-RAF and NRas mutated melanoma as a novel therapeutic strategy	2016
Dr Bernadette Carroll Professor Viktor Korolchuk	Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis	2015
Dr Graeme Hewitt Dr Bernadette Carroll Professor Viktor Korolchuk	Mechanisms of cross-talk between intracellular protein degradation pathways	2015
Professor Viktor Korolchuk Fiona Menzies	PI(5)P regulates autophagosome biogenesis	2015
Dr Bernadette Carroll Professor Penny Lovat Professor Viktor Korolchuk	Targeting the persistent activation of mammalian target of rapamycin in BRAF- and NRas-mutated melanoma as a novel therapeutic strategy	2015
Dr David McDonald Dr Bernadette Carroll Nicholas Robertson Dr Helen Griffin Professor Jeremy Lakey et al.	Dual Proteolytic Pathways Govern Glycolysis and Immune Competence	2014
Dr Piero Dalle Pezze Dr Glyn Nelson Gisela Otten Professor Viktor Korolchuk Emeritus Professor Thomas Kirkwood et al.	Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions	2014
Professor Viktor Korolchuk	Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease	2014
Dr Bernadette Carroll Dr Graeme Hewitt Professor Viktor Korolchuk	Autophagy and ageing: implications for age-related neurodegenerative diseases	2013
Dr Bernadette Carroll Professor Viktor Korolchuk	Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease	2013
Professor Viktor Korolchuk Dr Joao Passos	Lysosome-mediated processing of chromatin in senescence	2013
Professor Viktor Korolchuk	Guidelines for the use and interpretation of assays for monitoring autophagy	2012
Dr Diana Jurk Chunfang Wang Dr Satomi Miwa Mandy Maddick Professor Viktor Korolchuk et al.	Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response	2012
Professor Viktor Korolchuk	A Phagocytic Route for Uptake of Double-Stranded RNA in RNAi	2011
Professor Viktor Korolchuk	Complex inhibitory effects of nitric oxide on autophagy	2011
Professor Viktor Korolchuk	Lysosomal positioning coordinates cellular nutrient responses	2011
Professor Viktor Korolchuk	Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease	2010
Professor Viktor Korolchuk	Impaired autophagy in Lafora disease	2010
Professor Viktor Korolchuk	Laforin, the most common protein mutated in Lafora disease, regulates autophagy	2010
Professor Viktor Korolchuk	Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems	2010
Professor Viktor Korolchuk	Regulation of Mammalian Autophagy in Physiology and Pathophysiology	2010
Professor Viktor Korolchuk	A CD317/tetherin–RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells	2009
Professor Viktor Korolchuk	A novel link between autophagy and the ubiquitin-proteasome system	2009
Professor Viktor Korolchuk	Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates	2009
Professor Viktor Korolchuk	In search of an “autophagomometer”	2009
Professor Viktor Korolchuk	Mammalian macroautophagy at a glance	2009
Professor Viktor Korolchuk	Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates	2009
Professor Viktor Korolchuk	Huntington's disease: from pathology and genetics to potential therapies	2008
Professor Viktor Korolchuk	Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation	2007
Professor Viktor Korolchuk	Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif	2007
Professor Viktor Korolchuk	Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development	2007
Professor Viktor Korolchuk	Hippocalcin functions as a calcium sensor in hippocampal LTD	2005
Professor Viktor Korolchuk	Regulation of CK2 activity by phosphatidylinositol phosphates	2005
Professor Viktor Korolchuk	BST-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology	2003
Professor Viktor Korolchuk	Kinases in clathrin-mediated endocytosis	2003
Professor Viktor Korolchuk	CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles	2002
Professor Viktor Korolchuk	Activation of plasminogen by antiplasminogen monoclonal antibody IV-1c: Properties and mechanism of reaction	2000
Professor Viktor Korolchuk	Isolation and characterisation of antistreptokinase antibodies from blood serum of the patients treated by streptokinase	1999
Professor Viktor Korolchuk	Plasminogen binding with decapeptide and polypeptide fragments of streptokinase	1999
Professor Viktor Korolchuk	Val709-Glu724 streptokinase binding site of plasminogen interacts with streptokinase sequence Thr361-Arg372 during plasminogen - Streptokinase complex formation	1999