Dr Rozaliya Tsikandelova Eldo Galo Edvinas Cerniauskas Dr Dean Hallam Dr Maria Georgiou et al. | Retinal cells derived from patients with DRAM2-dependent CORD21 dystrophy exhibit key lysosomal enzyme deficiency and lysosomal content accumulation | 2024 |
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Dr Tetsushi Kataura Professor Viktor Korolchuk
| Ruthenium complex containing 1,3-thiazolidine-2-thione inhibits hepatic cancer stem cells by suppressing Akt/mTOR signalling and leading to apoptotic and autophagic cell death | 2024 |
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George Kelly Dr Tetsushi Kataura Dr Johan Panek Hanna Salmonowicz Hannah Kendall et al. | Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule | 2024 |
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Dr Tetsushi Kataura Lucy Sedlackova Niall Wilson Dr Satomi Miwa Dr Daniel Erskine et al. | Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models | 2024 |
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Dr Tetsushi Kataura Professor Viktor Korolchuk
| Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons | 2023 |
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Hanna Salmonowicz Dr James Chapman George Kelly Professor Laura Greaves Professor Derek Mann et al. | Apoptotic stress causes mtDNA release during senescence and drives the SASP | 2023 |
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Lucy Sedlackova Dr Tetsushi Kataura Professor Viktor Korolchuk
| Metabolic function of autophagy is essential for cell survival | 2023 |
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Lucy Sedlackova Dr Tetsushi Kataura Gisela Otten Professor Viktor Korolchuk
| NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency | 2023 |
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Professor Viktor Korolchuk
| Preface | 2023 |
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Professor Viktor Korolchuk
| Preface | 2023 |
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Niall Wilson Dr Tetsushi Kataura Professor Viktor Korolchuk
| The autophagy–NAD axis in longevity and disease | 2023 |
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Joshua Ratliffe Dr Tetsushi Kataura Gisela Otten Professor Viktor Korolchuk
| The evolution of selective autophagy as a mechanism of oxidative stress response: The evolutionarily acquired ability of selective autophagy receptors to respond to oxidative stress is beneficial for human longevity | 2023 |
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Dr Maria Georgiou Dr Chunbo Yang Rob Atkinson Dr Adriana Buskin Dr Joseph Collin et al. | Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient iPSC-derived retinal pigment epithelium cells | 2022 |
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Dr Tetsushi Kataura Lucy Sedlackova Gisela Otten David Shapira Dr Filippo Scialo et al. | Autophagy promotes cell survival by maintaining NAD levels | 2022 |
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Chanachai Sae-Lee Dr Timothy Barrow Dr Yoana Rabanal Ruiz Daniel Green Professor Viktor Korolchuk et al. | Genomic targets and selective inhibition of DNA methyltransferase isoforms | 2022 |
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Dr Tetsushi Kataura Gisela Otten Dr Yoana Rabanal Ruiz Francesca Urselli Dr Filippo Scialo et al. | NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy | 2022 |
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Dr Tetsushi Kataura Professor Viktor Korolchuk
| Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2 | 2022 |
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Dr Marzena Kurzawa-Akanbi Dr Florence Burte Dr Birthe Hilgen Dr Rachel Queen Dr Jonathan Coxhead et al. | Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina | 2022 |
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Dr Ed Fielder Dr Tengfei Wan Ghazaleh Alimohammadiha Abbas Ishaq Evon Low et al. | Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice | 2022 |
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Dr Jack Leslie Dr Hannah Paish Amy Collins Rebecca Scott Abi Watson et al. | A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis | 2021 |
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Marti Cadena Sandoval Dr Bernadette Carroll Professor Viktor Korolchuk
| G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling | 2021 |
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Dr Tengfei Wan Mary Johnson Professor Viktor Korolchuk Dr Gabriele Saretzki
| Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy | 2021 |
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Dr Daniel Erskine Dr David Koss Professor Viktor Korolchuk Professor Tiago Outeiro Professor Johannes Attems et al. | Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders | 2021 |
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Dr Yoana Rabanal Ruiz Lucy Sedlackova Dr Glyn Nelson Dr Bernadette Carroll Professor Viktor Korolchuk et al. | mTORC1 activity is supported by spatial association with focal adhesions | 2021 |
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Professor Viktor Korolchuk
| Ochratoxin A induces NLRP3 inflammasome-mediated pyroptosis via activation of ROS modulated by autophagy in vitro | 2021 |
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Professor Viktor Korolchuk
| Autophagy in Neurodegenerative Diseases | 2020 |
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Edvinas Cerniauskas Dr Marzena Kurzawa-Akanbi Dr Long Xie Dr Dean Hallam Marina Moya Molina et al. | Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function | 2020 |
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Professor Viktor Korolchuk
| Redox signalling in physiology, ageing and disease | 2020 |
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Lucy Sedlackova Professor Viktor Korolchuk
| The crosstalk of NAD, ROS and autophagy in cellular health and ageing | 2020 |
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Lucy Sedlackova George Kelly Professor Viktor Korolchuk
| The pROS of Autophagy in Neuronal Health | 2020 |
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Lucy Sedlackova Professor Viktor Korolchuk
| Mitochondrial quality control as a key determinant of cell survival | 2019 |
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Professor Viktor Korolchuk Dr Bernadette Carroll
| PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis | 2019 |
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Professor Viktor Korolchuk
| Preface | 2019 |
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Clara Correia Melo Dr Jodie Birch Dr Ed Fielder Dr James Chapman Dr Anthony Lagnado et al. | Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice | 2019 |
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Dr Olena Kucheryavenko Dr Glyn Nelson Professor Thomas von Zglinicki Professor Viktor Korolchuk Dr Bernadette Carroll et al. | The mTORC1-autophagy pathway is a target for senescent cell elimination | 2019 |
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Professor Viktor Korolchuk
| Autophagy: 'Self-Eating' Your Way to Longevity | 2018 |
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Dr Yoana Rabanal Ruiz Professor Viktor Korolchuk
| mTORC1 and nutrient homeostasis: The central role of the lysosome | 2018 |
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Dr Bernadette Carroll Professor Viktor Korolchuk
| Nutrient sensing, growth and senescence | 2018 |
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Dr Bernadette Carroll Diego Manni Dr Rhoda Stefanatos Fiona Menzies Dr Graham Smith et al. | Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis | 2018 |
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Professor Robin Harris Professor Viktor Korolchuk
| Preface | 2018 |
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Dr Yoshiki Hase Dr Aiqing Chen Dr Lucinda Craggs Yumi Yamamoto Lizzie Gemmell et al. | Severe white matter astrocytopathy in CADASIL | 2018 |
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Professor Viktor Korolchuk Dr Kehe Huang Dr XingXiang Chen
| Taurine attenuates OTA-promoted PCV2 replication through blocking ROS-dependent autophagy via inhibiting AMPK/mTOR signaling pathway | 2018 |
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Dr Dean Hallam Dr Joseph Collin Dr Sanja Bojic Dr Valeria Chichagova Dr Adriana Buskin et al. | An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure | 2017 |
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Dr Bernadette Carroll Professor Viktor Korolchuk
| Dysregulation of mTORC1/autophagy axis in senescence | 2017 |
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Professor Viktor Korolchuk Dr Satomi Miwa Dr Bernadette Carroll Professor Thomas von Zglinicki
| Mitochondria in cell senescence: Is mitophagy the weakest link? | 2017 |
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Dr Yoana Rabanal Ruiz Gisela Otten Professor Viktor Korolchuk
| mTORC1 as the main gateway to autophagy | 2017 |
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Dr Bernadette Carroll Dr Glyn Nelson Dr Yoana Rabanal Ruiz Dr Olena Kucheryavenko Professor Penny Lovat et al. | Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing | 2017 |
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Professor Viktor Korolchuk
| Selenomethionine Alleviates AFB1-Induced Damage in Primary Chicken Hepatocytes by Inhibiting CYP450 1A5 Expression via Upregulated SelW Expression | 2017 |
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Professor Viktor Korolchuk Dr James Murray
| Signalling mechanisms in autophagy: An introduction to the issue | 2017 |
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Dr Nuria Martinez Lopez Gisela Otten Dr Bernadette Carroll Professor Rajat Singh Professor Viktor Korolchuk et al. | Autophagy, lipophagy and lysosomal lipid storage disorders | 2016 |
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Dr Bernadette Carroll Gisela Otten Matthew Ratcliff Dr Graham Smith Dr Joao Passos et al. | Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity | 2016 |
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Professor Viktor Korolchuk Dr Bernadette Carroll Professor Penny Lovat Dr Nuria Martinez Lopez
| Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Ed.) | 2016 |
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Dr Clara Correia Melo Francisco Marques Rhys Anderson Dr Graeme Hewitt Dr Bernadette Carroll et al. | Mitochondria are required for pro-ageing features of the senescent phenotype | 2016 |
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Gisela Otten Diego Manni Professor Viktor Korolchuk
| Mitochondrial degradation, autophagy and neurodegenerative disease | 2016 |
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Diego Manni Professor Viktor Korolchuk
| Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure | 2016 |
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Gisela Otten Professor Viktor Korolchuk
| PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder | 2016 |
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Dr Graeme Hewitt Professor Viktor Korolchuk
| Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance | 2016 |
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Dr Graeme Hewitt Dr Bernadette Carroll Dr Clara Correia Melo Mikolaj Ogrodnik Dr Glyn Nelson et al. | SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair | 2016 |
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Dr Bernadette Carroll Dr Long Xie Professor Penny Lovat Professor Viktor Korolchuk
| Targeting the persistent activation of mammalian target of rapamycin in BRAF mutated melanoma as a novel therapeutic strategy | 2016 |
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Professor Viktor Korolchuk Dr Bernadette Carroll Dr Long Xie Carola Dostal Professor Penny Lovat et al. | Targeting the persistent activation of mTOR in B-RAF and NRas mutated melanoma as a novel therapeutic strategy | 2016 |
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Dr Bernadette Carroll Professor Viktor Korolchuk
| Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis | 2015 |
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Dr Graeme Hewitt Dr Bernadette Carroll Professor Viktor Korolchuk
| Mechanisms of cross-talk between intracellular protein degradation pathways | 2015 |
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Professor Viktor Korolchuk Fiona Menzies
| PI(5)P regulates autophagosome biogenesis | 2015 |
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Dr Bernadette Carroll Professor Penny Lovat Professor Viktor Korolchuk
| Targeting the persistent activation of mammalian target of rapamycin in BRAF- and NRas-mutated melanoma as a novel therapeutic strategy | 2015 |
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Dr David McDonald Dr Bernadette Carroll Nicholas Robertson Dr Helen Griffin Professor Jeremy Lakey et al. | Dual Proteolytic Pathways Govern Glycolysis and Immune Competence | 2014 |
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Dr Piero Dalle Pezze Dr Glyn Nelson Gisela Otten Professor Viktor Korolchuk Emeritus Professor Thomas Kirkwood et al. | Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions | 2014 |
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Professor Viktor Korolchuk
| Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease | 2014 |
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Dr Bernadette Carroll Dr Graeme Hewitt Professor Viktor Korolchuk
| Autophagy and ageing: implications for age-related neurodegenerative diseases | 2013 |
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Dr Bernadette Carroll Professor Viktor Korolchuk
| Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease | 2013 |
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Professor Viktor Korolchuk Dr Joao Passos
| Lysosome-mediated processing of chromatin in senescence | 2013 |
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Professor Viktor Korolchuk
| Guidelines for the use and interpretation of assays for monitoring autophagy | 2012 |
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Dr Diana Jurk Chunfang Wang Dr Satomi Miwa Mandy Maddick Professor Viktor Korolchuk et al. | Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response | 2012 |
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Professor Viktor Korolchuk
| A Phagocytic Route for Uptake of Double-Stranded RNA in RNAi | 2011 |
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Professor Viktor Korolchuk
| Complex inhibitory effects of nitric oxide on autophagy | 2011 |
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Professor Viktor Korolchuk
| Lysosomal positioning coordinates cellular nutrient responses | 2011 |
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Professor Viktor Korolchuk
| Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease | 2010 |
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Professor Viktor Korolchuk
| Impaired autophagy in Lafora disease | 2010 |
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Professor Viktor Korolchuk
| Laforin, the most common protein mutated in Lafora disease, regulates autophagy | 2010 |
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Professor Viktor Korolchuk
| Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems | 2010 |
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Professor Viktor Korolchuk
| Regulation of Mammalian Autophagy in Physiology and Pathophysiology | 2010 |
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Professor Viktor Korolchuk
| A CD317/tetherin–RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells | 2009 |
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Professor Viktor Korolchuk
| A novel link between autophagy and the ubiquitin-proteasome system | 2009 |
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Professor Viktor Korolchuk
| Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates | 2009 |
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Professor Viktor Korolchuk
| In search of an “autophagomometer” | 2009 |
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Professor Viktor Korolchuk
| Mammalian macroautophagy at a glance | 2009 |
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Professor Viktor Korolchuk
| Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates | 2009 |
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Professor Viktor Korolchuk
| Huntington's disease: from pathology and genetics to potential therapies | 2008 |
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Professor Viktor Korolchuk
| Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation | 2007 |
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Professor Viktor Korolchuk
| Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif | 2007 |
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Professor Viktor Korolchuk
| Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development | 2007 |
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Professor Viktor Korolchuk
| Hippocalcin functions as a calcium sensor in hippocampal LTD | 2005 |
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Professor Viktor Korolchuk
| Regulation of CK2 activity by phosphatidylinositol phosphates | 2005 |
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Professor Viktor Korolchuk
| BST-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology | 2003 |
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Professor Viktor Korolchuk
| Kinases in clathrin-mediated endocytosis | 2003 |
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Professor Viktor Korolchuk
| CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles | 2002 |
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Professor Viktor Korolchuk
| Activation of plasminogen by antiplasminogen monoclonal antibody IV-1c: Properties and mechanism of reaction | 2000 |
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Professor Viktor Korolchuk
| Isolation and characterisation of antistreptokinase antibodies from blood serum of the patients treated by streptokinase | 1999 |
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Professor Viktor Korolchuk
| Plasminogen binding with decapeptide and polypeptide fragments of streptokinase | 1999 |
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Professor Viktor Korolchuk
| Val709-Glu724 streptokinase binding site of plasminogen interacts with streptokinase sequence Thr361-Arg372 during plasminogen - Streptokinase complex formation | 1999 |
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