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The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial

Lookup NU author(s): Dr Tom Clifford, Dr Dean AllertonORCiD, Sarah Stansfield, Professor Emma Stevenson



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


This study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation and bone turnover. Using a double-blind, independent group’s design, 24 recreationally active males consumed either 20 g day−1 of CP or a placebo control (CON) for 7 days before and 2 days after performing 150 drop jumps. Maximal isometric voluntary contractions, countermovement jumps (CMJ), muscle soreness (200 mm visual analogue scale), pressure pain threshold, Brief Assessment of Mood Adapted (BAM +) and a range of blood markers associated with muscle damage, inflammation and bone turnover C-terminal telopeptide of type 1 collagen (β-CTX) and N-terminal propeptides of type 1 pro-collagen (P1NP) were measured before supplementation (baseline; BL), pre, post, 1.5, 24 and 48 h post-exercise. Muscle soreness was not significantly different in CP and CON (P = 0.071) but a large effect size was evident at 48 h post-exercise, indicative of lower soreness in the CP group (90.42 ± 45.33 mm vs. CON 125.67 ± 36.50 mm; ES = 2.64). CMJ height recovered quicker with CP than CON at 48 h (P = 0.050; CP 89.96 ± 12.85 vs. CON 78.67 ± 14.41% of baseline values; ES = 0.55). There were no statistically significant effects for the other dependent variables (P > 0.05). β-CTX and P1NP were unaffected by CP supplementation (P > 0.05). In conclusion, CP had moderate benefits for the recovery of CMJ and muscle soreness but had no influence on inflammation and bone collagen synthesis.

Publication metadata

Author(s): Clifford T, Ventress M, Allerton DM, Stansfield S, Tang JCY, Fraser WD, Vanhoecke B, Prawitt J, Stevenson E

Publication type: Article

Publication status: Published

Journal: Amino Acids

Year: 2019

Volume: 51

Pages: 691–704

Print publication date: 01/04/2019

Online publication date: 19/02/2019

Acceptance date: 19/01/2019

Date deposited: 20/02/2019

ISSN (print): 0939-4451

ISSN (electronic): 1438-2199

Publisher: Springer


DOI: 10.1007/s00726-019-02706-5


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