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Revised upper limb module for spinal muscular atrophy: 12 month changes

Lookup NU author(s): Dr Anna Mayhew, Robert Muni Lofra, Professor Volker Straub

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Abstract

© 2019 Wiley Periodicals, Inc.Introduction: The aim of the study was to assess 12 month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3. Methods: Longitudinal 12 month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module. Results: The 12 month changes ranged between -7 and 9 (mean: -0.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (-0.45 in type 2, -0.23 in non-ambulant type 3 and -0.34 in ambulant type 3, p = 0.96) and the relationship between 12 month change and age classes was not significantly different among the three types of SMA patients. Discussion: Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non-ambulant patients of different ages in conjunction with other functional scales. Muscle Nerve, 2019.


Publication metadata

Author(s): Pera MC, Coratti G, Mazzone ES, Montes J, Scoto M, De Sanctis R, Main M, Mayhew A, Muni Lofra R, Dunaway Young S, Glanzman AM, Duong T, Pasternak A, Ramsey D, Darras B, Day JW, Finkel RS, De Vivo DC, Sormani MP, Bovis F, Straub V, Muntoni F, Pane M, Mercuri E

Publication type: Article

Publication status: Published

Journal: Muscle and Nerve

Year: 2019

Volume: 59

Issue: 4

Pages: 426-430

Print publication date: 13/03/2019

Online publication date: 24/01/2019

Acceptance date: 19/01/2019

ISSN (print): 0148-639X

ISSN (electronic): 1097-4598

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1002/mus.26419

DOI: 10.1002/mus.26419


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