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Widespread microglial activation in multiple system atrophy

Lookup NU author(s): Professor David BrooksORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. Background: The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [ 11 C](R)-PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients. Methods: Fourteen patients with the parkinsonian phenotype of MSA (MSA-P) with a mean disease duration of 2.9 years (range 2-5 years) were examined with [ 11 C](R)-PK11195 PET and compared with 10 healthy controls. Results: Patients with the parkinsonian phenotype of MSA showed a significant (P ≤ 0.01) mean increase in binding potentials compared with healthy controls in the caudate nucleus, putamen, pallidum, precentral gyrus, orbitofrontal cortex, presubgenual anterior cingulate cortex, and the superior parietal gyrus. No correlations between binding potentials and clinical parameters were found. Conclusions: In early clinical stages of the parkinsonian phenotype of MSA, there is widespread microglial activation as a marker of neuroinflammatory changes without correlation to clinical parameters in our patient population. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.


Publication metadata

Author(s): Kubler D, Wachter T, Cabanel N, Su Z, Turkheimer FE, Dodel R, Brooks DJ, Oertel WH, Gerhard A

Publication type: Article

Publication status: Published

Journal: Movement Disorders

Year: 2019

Volume: 34

Issue: 4

Pages: 564-568

Print publication date: 16/04/2019

Online publication date: 06/02/2019

Acceptance date: 02/01/2019

Date deposited: 01/03/2019

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1002/mds.27620

DOI: 10.1002/mds.27620


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Funding

Funder referenceFunder name
Action Research. Grant Number: SP 3615
Charitable Hertie Foundation, Frankfurt, Germany
FP7/2007‐2013
MRC
Parkinson's Disease Society UK. Grant Number: MAP 02/04

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