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Lookup NU author(s): Professor David BrooksORCiD
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Society of Nuclear Medicine, 2019.
For re-use rights please refer to the publisher's terms and conditions.
Cerebrospinal fluid plays an important role in the clearance of solutes and maintenance of brain homeostasis. Early detection of diminished brain waste clearance could serve a vital role in the prevention, effective treatment, and early diagnosis of some neurological disorders, although a proper biomarker is missing. 11C-PiB PET was recently proposed as a tool for detection of CSF clearance alterations in Alzheimer’s disease. The current study seeks to investigate the magnitude of 11C-PiB PET signal in the lateral ventricles of an independent group of Alzheimer’s and mild cognitive impairment subjects. We have also evaluated multiple sclerosis as a model of disease with CSF clearance alterations without amyloid-beta tissue accumulation. A set of Alzheimer’s and mild cognitive impairment subjects and a set of multiple sclerosis subjects with matched healthy controls underwent MRI and dynamic 11C-PiB PET. Manual lateral ventricle regions of interest were generated from MRI data. PET data was analysed using a simplified reference tissue model with cerebellum or a supervised reference region, for the Alzheimer’s and multiple sclerosis datasets, respectively. Magnitude of 11C-PiB signal in the lateral ventricles was calculated as area under curve from 35 to 80 minutes and standard uptake value ratio (SUVR) from 50 to 70 minutes. Compartmental modelling analysis was performed on a separate dataset containing Alzheimer’s and matched healthy control data with an arterial input function to further understand the kinetics of the lateral ventricular 11C-PiB signal and better interpret our results. Analysis of variance revealed significant group differences in lateral ventricular SUVR across the Alzheimer’s, mild cognitive impairment, and healthy control groups (p=0.004). Additional pairwise comparisons revealed significantly lower lateral ventricular SUVR in Alzheimer’s disease compared to healthy controls (p<0.001) and compared to mild cognitive impairment (p=0.029). Lateral ventricular SUVR was also significantly lower in multiple sclerosis patients compared to healthy controls (p=0.008). Compartmental modelling analysis revealed significantly lower uptake rates of 11C-PiB signal from the blood (p=0.005) and from the brain tissue (p=0.004) to the lateral ventricles in Alzheimer’s patients compared to healthy controls. This analysis also revealed significantly lower clearance of 11C-PiB signal out of the lateral ventricles in Alzheimer’s patients compared to healthy controls (p=0.002). Overall, these results indicate that dynamic 11C-PiB PET can be used to observe pathological changes in cerebrospinal fluid dynamics and that cerebrospinal fluid-mediated clearance is reduced in Alzheimer’s disease and multiple sclerosis compared to healthy controls.
Author(s): Schubert JJ, Veronese M, Marchitelli L, Bodini B, Tonietto M, Stankoff B, Brooks DJ, Bertoldo A, Edison P, Turkheimer FE
Publication type: Article
Publication status: Published
Journal: Journal of Nuclear Medicine
Print publication date: 01/10/2019
Online publication date: 08/03/2019
Acceptance date: 20/02/2019
Date deposited: 27/02/2019
ISSN (print): 0161-5505
ISSN (electronic): 1535-5667
Publisher: Society of Nuclear Medicine
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