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Top research priorities in liver and gallbladder disorders in the UK

Lookup NU author(s): Dr Steven MassonORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objectives There is a mismatch between research questions considered important by patients, carers and healthcare professionals and the research performed in many fields of medicine. The non-alcohol-related liver and gallbladder disorders priority setting partnership was established to identify the top research priorities in the prevention, diagnostic and treatment of gallbladder disorders and liver disorders not covered by the James-Lind Alliance (JLA) alcohol-related liver disease priority setting partnership. Design The methods broadly followed the principles of the JLA guidebook. The one major deviation from the JLA methodology was the final step of identifying priorities: instead of prioritisation by group discussions at a consensus workshop involving stakeholders, the prioritisation was achieved by a modified Delphi consensus process. Results A total of 428 unique valid diagnostic or treatment research questions were identified. A literature review established that none of these questions were considered a € answered' that is, high-quality systematic reviews suggest that further research is not required on the topic. The Delphi panel achieved consensus (at least 80% Delphi panel members agreed) that a research question was a top research priority for six questions. Four additional research questions with highest proportion of Delphi panel members ranking the question as highly important were added to constitute the top 10 research priorities. Conclusions A priority setting process involving patients, carers and healthcare professionals has been used to identify the top 10priority areas for research related to liver and gallbladder disorders. Basic, translational, clinical and public health research are required to address these uncertainties.

Publication metadata

Author(s): Gurusamy KS, Walmsley M, Davidson BR, Frier C, Fuller B, Madden A, Masson S, Morley R, Safarik I, Tsochatzis EA, Ahmed I, Cowlin M, Dillon JF, Ellicott G, Elsharkawy AM, Farrington L, Glachan A, Kumar N, Milne EJ, Rushbrook SM, Smith A, Stafford L, Yeoman A

Publication type: Article

Publication status: Published

Journal: BMJ Open

Year: 2019

Volume: 9

Issue: 3

Online publication date: 07/03/2019

Acceptance date: 07/02/2019

Date deposited: 20/03/2019

ISSN (electronic): 2044-6055

Publisher: BMJ Publishing Group


DOI: 10.1136/bmjopen-2018-025045

PubMed id: 30850408


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