Lookup NU author(s): Dr Simon Tual-Chalot,
Professor Konstantinos Stellos
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2019 Cardiovascular disease (CVD) remains the leading cause of death in the Western world. Despite advances in the prevention and in the management of CVD, the role of RNA epigenetics in the cardiovascular system has been until recently unexplored. The rapidly expanding research field of RNA modifications has introduced a novel layer of gene regulation in mammalian cells. RNA modifications may control all aspects of RNA metabolism, and their study reveals previously unrecognized regulatory pathways that may determine gene expression at a post-transcriptional level. Understanding the role of RNA modifications in CVD may lead towards a better understanding of disease mechanisms and the development of novel biomarkers or therapeutic strategies. In this review, we highlight the most recent and major reports in the field of RNA methylation and adenosine to inosine RNA editing related to the cardiovascular field and we discuss how this breakthrough will advance the field of precision medicine.
Author(s): Dorn LE, Tual-Chalot S, Stellos K, Accornero F
Publication type: Article
Publication status: Published
Journal: Journal of Molecular and Cellular Cardiology
Print publication date: 01/04/2019
Online publication date: 14/03/2019
Acceptance date: 11/03/2019
ISSN (print): 0022-2828
ISSN (electronic): 1095-8584
Publisher: Academic Press
PubMed id: 30880252
Altmetrics provided by Altmetric