Publications by Dr Simon Tual-Chalot - ePrints

Browsing publications by Dr Simon Tual-Chalot.

Newcastle Authors	Title	Year
Dr Georgios Georgiopoulos Dr Simon Tual-Chalot Dr Kateryna Sopova Professor Konstantinos Stellos Professor Kimon Stamatelopoulos et al.	Amyloid-beta metabolism in age-related neurocardiovascular diseases	2025
Dr Georgios Georgiopoulos Dr Simon Tual-Chalot Dr Kateryna Sopova Professor Konstantinos Stellos Professor Kimon Stamatelopoulos et al.	Incremental Value of Blood-Based Markers of Liver Fibrosis in Cardiovascular Risk Stratification	2025
Dr Simon Tual-Chalot Dr Satomi Miwa Professor Gavin Richardson Professor Ioakim Spyridopoulos Professor Konstantinos Stellos et al.	Roadmap for alleviating the manifestations of ageing in the cardiovascular system	2025
Dr Simon Tual-Chalot Professor Konstantinos Stellos Professor Kimon Stamatelopoulos	Amyloid beta is associated with carotid wall echolucency and atherosclerotic plaque composition	2024
Dr Rachael Redgrave Dr Esha Singh Dr Simon Tual-Chalot Dr Catherine Park Dr Darroch Hall et al.	Exogenous Transforming Growth Factor-β1 and Its Helminth-Derived Mimic Attenuate the Heart's Inflammatory Response to Ischemic Injury and Reduce Mature Scar Size	2024
Dr Simon Tual-Chalot Professor Konstantinos Stellos	First-in-human gene editing for lipid lowering: the initial results	2024
Dr Maria Camacho Encina Laura Booth Dr Rachael Redgrave Minna Honkanen-Scott Dr Bill Scott et al.	Identifying optimal reference genes for real-time quantitative polymerase chain reaction in human myocardial tissues	2024
Dr Simon Tual-Chalot	Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries	2024
Dr Simon Tual-Chalot Professor Konstantinos Stellos	Repurposing of an antiasthmatic drug may reduce NETosis and myocardial ischaemia/reperfusion injury	2024
Dr Kateryna Sopova Dr Simon Tual-Chalot Dr Nikolaos Vlachogiannis Dr Georgios Georgiopoulos Dr Luke Spray et al.	Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction	2023
Laura Booth Dr Rachael Redgrave Dr Simon Tual-Chalot Professor Ioakim Spyridopoulos Dr Helen Phillips et al.	Heart Disease and Ageing: The Roles of Senescence, Mitochondria, and Telomerase in Cardiovascular Disease	2023
Dr Georgios Georgiopoulos Dr Kateryna Sopova Dr Luke Spray Dr Jose Coelho Lima Junior Dr Simon Tual-Chalot et al.	Modification of the GRACE Risk Score for Risk Prediction in Patients with Acute Coronary Syndromes	2023
Dr Simon Tual-Chalot Professor Kimon Stamatelopoulos Dr Aikaterini Gatsiou Professor Konstantinos Stellos	RNA-binding proteins in vascular inflammation and atherosclerosis	2023
Dr Rachael Redgrave Dr Emily Dookun Laura Booth Dr Maria Camacho Encina Dr Omowumi Folaranmi et al.	Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction	2023
Dr Aikaterini Gatsiou Dr Simon Tual-Chalot Dr Georgios Georgiopoulos Professor Kimon Stamatelopoulos Professor Ioakim Spyridopoulos et al.	The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation	2023
Dr Rachael Redgrave Dr Maria Camacho Encina Dr Simon Tual-Chalot Dr Omowumi Folaranmi Dr Carmen Martin-Ruiz et al.	The senescence-associated secretory phenotype as a biomarker for age-related myocardial remodelling and cardiovascular disease	2023
Dr Simon Tual-Chalot Dr Nikolaos Vlachogiannis Dr Kateryna Sopova Dr Aikaterini Gatsiou Dr Georgios Georgiopoulos et al.	Beta-secretase-1 antisense RNA is associated with vascular ageing and atherosclerotic cardiovascular disease	2022
Professor Kimon Stamatelopoulos Dr Georgios Georgiopoulos Dr Nikolaos Vlachogiannis Dr Kateryna Sopova Dr Simon Tual-Chalot et al.	Cathepsin S Levels and Survival Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes	2022
Dr Simon Tual-Chalot Professor Konstantinos Stellos	Chrono-pharmacology-based antiplatelet therapy for acute myocardial infarction	2022
Dr Nikolaos Vlachogiannis Dr Ken Baker Dr Georgios Georgiopoulos Dr Ina Schim van der Loeff Dr Aidan Hanrath et al.	Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study	2022
Dr Simon Tual-Chalot Professor Konstantinos Stellos	Noncoding RNAs in age-related cardiovascular diseases	2022
Dr Simon Tual-Chalot Professor Konstantinos Stellos	Targeting the adipose tissue: heart crosstalk in pressure overload-induced heart failure	2022
Dr Anna Walaszczyk Dr Emily Dookun Dr Rachael Redgrave Dr Pawel Palmowski Dr Simon Tual-Chalot et al.	Therapeutic potential of navitoclax in age-related cardiovascular diseases	2022
Dr Aikaterini Gatsiou Dr Georgios Georgiopoulos Dr Nikolaos Vlachogiannis Dr Simon Tual-Chalot Lefteris Zormpas et al.	Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis	2021
Dr Nikolaos Vlachogiannis Dr Simon Tual-Chalot Lefteris Zormpas Professor Kimon Stamatelopoulos Dr Aikaterini Gatsiou et al.	Adenosine-to-inosine RNA editing contributes to type I interferon responses in systemic sclerosis	2021
Dr Simon Tual-Chalot Dr Nikolaos Vlachogiannis Professor Konstantinos Stellos Professor Kimon Stamatelopoulos	Circulating Amyloid Beta 1-40 Is Associated with Increased Rate of Progression of Atherosclerosis in Menopause: A Prospective Cohort Study	2021
Dr Simon Tual-Chalot Professor Konstantinos Stellos	MicroRNA-based therapy of postmyocardial infarction heart failure	2021
Dr Simon Tual-Chalot Professor Konstantinos Stellos	Therapeutic potential of adenosine kinase inhibition in vascular disease	2021
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Pawel Palmowski Dr Simon Tual-Chalot et al.	Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery	2020
Dr Simon Tual-Chalot Dr Rachael Redgrave Dr Esha Singh Dr Benjamin Davison Dr Catherine Park et al.	Loss of endothelial Endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signalling	2020
Professor Kimon Stamatelopoulos Lefteris Zormpas Dr Nikolaos Vlachogiannis Dr Simon Tual-Chalot Professor Konstantinos Stellos et al.	The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar	2020
Dr Nikolaos Vlachogiannis Dr Kateryna Sopova Dr Simon Tual-Chalot Dr Aikaterini Gatsiou Professor Konstantinos Stellos et al.	Cathepsin B expression is associated with arterial stiffening and atherosclerotic vascular disease	2019
Dr Kate Bailey Dr Guy MacGowan Dr Simon Tual-Chalot Lauren Charlotte Phillips Phillips Professor Deborah Henderson et al.	Disruption of embryonic ROCK signalling reproduces the sarcomeric phenotype of Hypertrophic Cardiomyopathy	2019
Rhys Anderson Anthony Lagnado Damien Maggiorani Dr Anna Walaszczyk Emily Dookun et al.	Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence	2019
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury	2019
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Dr Simon Tual-Chalot Professor Ioakim Spyridopoulos et al.	Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.	2019
Dr Simon Tual-Chalot Professor Konstantinos Stellos	RNA epigenetics and cardiovascular diseases	2019
Oliver Yausep Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot et al.	The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury	2019
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?	2018
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury.	2018
Dr Simon Tual-Chalot Professor Helen Arthur	Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2	2018
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Dr Simon Tual-Chalot Rhys Anderson et al.	Senescence as a therapeutic target for myocardial ageing	2018
Eunate Gallardo Vara Dr Simon Tual-Chalot Professor Helen Arthur	Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia	2018
Dr Rachael Redgrave Dr Simon Tual-Chalot Dr Benjamin Davison Dr Esha Singh Dr Darroch Hall et al.	Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis	2017
Dr Simon Tual-Chalot Dr Rachael Redgrave Professor Helen Arthur	Loss of Endothelial Endoglin Leads to Heart Failure	2016
Professor Bob Anderson Dr Simon Tual-Chalot Dr Rachael Redgrave Rebecca Dodds Dr Andrew Owens et al.	The role of cardiomyocyte senescence and regeneration in Ageing	2016
Dr Rachael Redgrave Dr Simon Tual-Chalot Dr Benjamin Davison Liz Greally Dr Mauro Santibanez Koref et al.	Using MRI to predict future adverse cardiac remodelling in a male mouse model of myocardial infarction	2016
Dr Simon Tual-Chalot Dr Benjamin Davison Dr Rachael Redgrave Professor Helen Arthur	Endoglin is required to maintain normal cardiac function in adult life	2015
Dr Simon Tual-Chalot Professor Helen Arthur	Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges	2015
Dr Simon Tual-Chalot	Circulating microparticles from obstuctive sleep apnea syndrome patients induce endothelin-mediated angiogenesis	2014
Dr Simon Tual-Chalot Dr Marwa Mahmoud Kathleen Allinson Dr Rachael Redgrave Professor Helen Arthur et al.	Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression	2014
Dr Simon Tual-Chalot Dr Rachael Redgrave Professor Helen Arthur	Endothelial expression of endoglin and Acvrl1 are required for normal vascular patterning during developmental angiogenesis and for maintaining adult vessel integrity	2014
Dr Simon Tual-Chalot Kathleen Allinson Professor Helen Arthur	Whole Mount Immunofluorescent Staining of the Neonatal Mouse Retina to Investigate Angiogenesis In vivo	2013
Dr Simon Tual-Chalot	Circulating microparticles from patients with obstructive sleep apnea enhance vascular contraction: mandatory role of the endothelium	2012
Dr Simon Tual-Chalot	Increased microparticle production and impaired microvascular endothelial function in aldosterone-salt-treated rats: protective effects of polyphenols	2012
Dr Simon Tual-Chalot	Microparticle release in remote ischemic conditioning mechanism	2012
Dr Simon Tual-Chalot	Increased oxidative stress induces apoptosis in human cystic fibrosis cells.	2011
Dr Simon Tual-Chalot	Microparticles: targets and tools in cardiovascular disease	2011
Dr Simon Tual-Chalot	Microvesicles: intercellular vectors of biological messages.	2011
Dr Simon Tual-Chalot	Nocturnal release of leukocyte-derived microparticles in males with obstructive sleep apnoea.	2011
Dr Simon Tual-Chalot	Circulating microparticles from pulmonary hypertensive rats induce endothelial dysfunction.	2010
Dr Simon Tual-Chalot	PPARα is essential for microparticle-induced differentiation of mouse bone marrow-derived endothelial progenitor cells and angiogenesis	2010