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Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence

Lookup NU author(s): Dr Mikolaj Ogrodnik, Hanna Salmonowicz, Dr Diana JurkORCiD, Dr Joao Passos

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Abstract

© 2019 Elsevier Ltd. Cellular senescence is a major driver of age-related diseases, and senotherapies are being tested in clinical trials. Despite its popularity, cellular senescence is weakly defined and is frequently referred to as irreversible cell-cycle arrest. In this article we hypothesize that cellular senescence is a phenotype that results from the coordination of two processes: cell expansion and cell-cycle arrest. We provide evidence for the compatibility of the proposed model with recent findings showing senescence in postmitotic tissues, wound healing, obesity, and development. We believe our model also explains why some characteristics of senescence can be found in non-senescent cells. Finally, we propose new avenues for research from our model.

Publication metadata

Author(s): Ogrodnik M, Salmonowicz H, Jurk D, Passos JF

Publication type: Review

Publication status: Published

Journal: Trends in Biochemical Sciences

Year: 2019

Volume: 44

Issue: 12

Pages: 996-1008

Print publication date: 01/12/2019

Online publication date: 22/07/2019

Acceptance date: 02/04/2018

ISSN (print): 0968-0004

ISSN (electronic): 1362-4326

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.tibs.2019.06.011

DOI: 10.1016/j.tibs.2019.06.011

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