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Lookup NU author(s): Dr Mikolaj Ogrodnik,
Dr Diana JurkORCiD,
Dr Joao Passos
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© 2019 Elsevier Ltd. Cellular senescence is a major driver of age-related diseases, and senotherapies are being tested in clinical trials. Despite its popularity, cellular senescence is weakly defined and is frequently referred to as irreversible cell-cycle arrest. In this article we hypothesize that cellular senescence is a phenotype that results from the coordination of two processes: cell expansion and cell-cycle arrest. We provide evidence for the compatibility of the proposed model with recent findings showing senescence in postmitotic tissues, wound healing, obesity, and development. We believe our model also explains why some characteristics of senescence can be found in non-senescent cells. Finally, we propose new avenues for research from our model.
Author(s): Ogrodnik M, Salmonowicz H, Jurk D, Passos JF
Publication type: Review
Publication status: Published
Journal: Trends in Biochemical Sciences
Print publication date: 01/12/2019
Online publication date: 22/07/2019
Acceptance date: 02/04/2018
ISSN (print): 0968-0004
ISSN (electronic): 1362-4326
Publisher: Elsevier Ltd