Browse by author
Lookup NU author(s): Dr Kathryn Musgrave,
Dr Peter Carey,
Dr Tina Biss
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2019 Lippincott Williams and Wilkins. All rights reserved.Myeloproliferative neoplasms (MPNs) in childhood and adolescence are rare and seldom complicated by thrombosis. We describe 3 cases of thrombosis at unusual sites in young patients with MPNs. In the pediatric MPN population, unlike in adult MPNs, a clonal mutation is identifiable in only a minority of cases (22% to 26%). All 3 of these individuals had JAK2 mutations driving the disease process. A literature search identified 19 cases of MPN-associated thrombosis in children. Seventeen of the 19 children (89.5%) had a driver mutation. These cases suggest that identifiable driver mutations may confer an increased thrombotic risk in children with MPNs.
Author(s): Tafesh L, Musgrave K, Roberts W, Plews D, Carey P, Biss T
Publication type: Article
Publication status: Published
Journal: Journal of Pediatric Hematology/Oncology
Print publication date: 01/08/2019
Acceptance date: 20/03/2018
ISSN (print): 1077-4114
ISSN (electronic): 1536-3678
Publisher: Lippincott Williams and Wilkins
Altmetrics provided by Altmetric