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Mucosal microbial parasites/symbionts in health and disease: an integrative overview

Lookup NU author(s): Professor Robert Hirt

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Cambridge University Press, 2019.

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Abstract

Microbial parasites adapted to thrive at mammalian mucosal surfaces have evolved multiple times from phylogenetically distant lineages into various extracellular and intracellular life styles. Their symbiotic relationships can range from commensalism to parasitism and more recently some host–parasites interactions are thought to have evolved into mutualistic associations too. It is increasingly appreciated that this diversity of symbiotic outcomes is the product of a complex network of parasites–microbiota–host interactions. Refinement and broader use of DNA based detection techniques are providing increasing evidence of how common some mucosal microbial parasites are and their host range, with some species being able to swap hosts, including from farm and pet animals to humans. A selection of examples will illustrate the zoonotic potential for a number of microbial parasites and how some species can be either disruptive or beneficial nodes in the complex networks of host–microbe interactions disrupting or maintaining mucosal homoeostasis. It will be argued that mucosal microbial parasitic diversity will represent an important resource to help us dissect through comparative studies the role of host–microbe interactions in both human health and disease.


Publication metadata

Author(s): Hirt RP

Publication type: Article

Publication status: Published

Journal: Parasitology

Year: 2019

Volume: 146

Issue: 9

Pages: 1109-1115

Print publication date: 05/08/2019

Online publication date: 05/08/2019

Acceptance date: 30/04/2019

Date deposited: 17/08/2019

ISSN (print): 0031-1820

ISSN (electronic): 1469-8161

Publisher: Cambridge University Press

URL: https://doi.org/10.1017/S0031182019000647

DOI: 10.1017/S0031182019000647

PubMed id: 31378213


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