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Lookup NU author(s): Dr Miguel Dasilva Ogando, Dr Christian Brandt, Dr Sascha Gotthardt, Dr Alwin GieselmannORCiD, Professor Alexander Thiele
This is the final published version of an article that has been published in its final definitive form by National Academy of Sciences, 2019.
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Attention is critical to high-level cognition, and attentional deficits are a hallmark of cognitive dysfunction. A key transmitter for attentional control is acetylcholine, but its cellular actions in attention controlling areas remain poorly understood. Here we delineate how muscarinic and nicotinic receptors affect basic neuronal excitability and attentional control signals in different cell types in macaque frontal eye-field. We found that broad spiking and narrow spiking cells both require muscarinic and nicotinic receptors for normal excitability, thereby affecting ongoing or stimulus driven activity. Attentional control signals depended on muscarinic, not nicotinic receptors in broad spiking cells, while it depended on both muscarinic and nicotinic receptors in narrow spiking cells. Cluster analysis revealed that muscarinic and nicotinic effects on attentional control signals were highly selective even for different subclasses of narrow spiking cells and of broad spiking cells. These results demonstrate that cholinergic receptors are critical to establish attentional control signals in the frontal eye field in a cell type specific manner.
Author(s): Dasila M, Brandt C, Gotthardt S, Gieselmann MA, Distler C, Thiele A
Publication type: Article
Publication status: Published
Journal: Proceedings of the National Academy of Sciences
Year: 2019
Volume: 116
Issue: 40
Pages: 20180-20189
Print publication date: 01/10/2019
Online publication date: 16/09/2019
Acceptance date: 17/08/2019
Date deposited: 20/08/2019
ISSN (print): 0027-8424
ISSN (electronic): 1091-6490
Publisher: National Academy of Sciences
URL: https://doi.org/10.1073/pnas.1905413116
DOI: 10.1073/pnas.1905413116
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