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Cell Class specific modulation of attentional signals by acetylcholine in macaque frontal eye field

Lookup NU author(s): Dr Miguel Dasilva Ogando, Dr Christian Brandt, Dr Sascha Gotthardt, Dr Alwin Gieselmann, Professor Alexander Thiele

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This is the final published version of an article that has been published in its final definitive form by National Academy of Sciences, 2019.

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Abstract

Attention is critical to high-level cognition, and attentional deficits are a hallmark of cognitive dysfunction. A key transmitter for attentional control is acetylcholine, but its cellular actions in attention controlling areas remain poorly understood. Here we delineate how muscarinic and nicotinic receptors affect basic neuronal excitability and attentional control signals in different cell types in macaque frontal eye-field. We found that broad spiking and narrow spiking cells both require muscarinic and nicotinic receptors for normal excitability, thereby affecting ongoing or stimulus driven activity. Attentional control signals depended on muscarinic, not nicotinic receptors in broad spiking cells, while it depended on both muscarinic and nicotinic receptors in narrow spiking cells. Cluster analysis revealed that muscarinic and nicotinic effects on attentional control signals were highly selective even for different subclasses of narrow spiking cells and of broad spiking cells. These results demonstrate that cholinergic receptors are critical to establish attentional control signals in the frontal eye field in a cell type specific manner.


Publication metadata

Author(s): Dasila M, Brandt C, Gotthardt S, Gieselmann MA, Distler C, Thiele A

Publication type: Article

Publication status: Published

Journal: Proceedings of the National Academy of Sciences

Year: 2019

Pages: ePub ahead of Print

Online publication date: 16/09/2019

Acceptance date: 17/08/2019

Date deposited: 20/08/2019

ISSN (print): 0027-8424

ISSN (electronic): 1091-6490

Publisher: National Academy of Sciences

URL: https://doi.org/10.1073/pnas.1905413116

DOI: 10.1073/pnas.1905413116


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