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Lookup NU author(s): Dr Paul Keane, Dr Peter Hanson, Lina Patterson, Professor Peter Blain, Philippa Hepplewhite, Dr Ahmad Khundakar, Dr Sarah Judge, Dr Fiona LeBeauORCiD, Dr Christopher Morris
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Parkinson's disease (PD) is characterised pathologically by degeneration of the dopaminergic (DA) neurones of the substantia nigra pars compacta (SNpc) and the presence of α-synuclein containing Lewy body inclusions. Trichloroethylene (TCE) has been suggested as a potential environmental chemical that may contribute to the development of PD, via conversion to the neurotoxin, 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo). We investigated the effect of an 8 week exposure to TCE or TaClo on wild type and, as an experimental model of PD, A30P mutant α-synuclein overexpressing mice using a combination of behaviour and pathology. TCE or TaClo exposure caused significant DA neuronal loss within the SNpc in both wild type and transgenic mice. Cell numbers were lower in A30P animals than wild type, however, no additive effect of TCE or TaClo exposure and A30P overexpression was found. TCE or TaClo did not appear to lead to acceleration of motor or cognitive deficits in either wild type or A30P mutant mice, potentially because of the modest reductions of DA neuronal number in the SNpc. Our results do however suggest that TCE exposure could be a possible factor in development of PD like changes following exposure
Author(s): Keane PC, Hanson PS, Patterson L, Blain PG, Hepplewhite P, Khundakar AA, Judge SJ, Kahle PJ, LeBeau FEN, Morris CM
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
Year: 2019
Volume: 711
Print publication date: 15/10/2019
Online publication date: 15/08/2019
Acceptance date: 14/08/2019
Date deposited: 03/09/2019
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
Publisher: Elsevier
URL: https://doi.org/10.1016/j.neulet.2019.134437
DOI: 10.1016/j.neulet.2019.134437
PubMed id: 31422098
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