Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

The diverse structural landscape of quadruplexes

Lookup NU author(s): Dr Natalie TatumORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© 2019 Federation of European Biochemical Societies.G-quadruplexes are secondary structures formed in G-rich sequences in DNA and RNA. Considerable research over the past three decades has led to in-depth insight into these unusual structures in DNA. Since the more recent exploration into RNA G-quadruplexes, such structures have demonstrated their in cellulo existence, function and roles in pathology. In comparison to Watson-Crick-based secondary structures, most G-quadruplexes display highly redundant structural characteristics. However, numerous reports of G-quadruplex motifs/structures with unique features (e.g. bulges, long loops, vacancy) have recently surfaced, expanding the repertoire of G-quadruplex scaffolds. This review addresses G-quadruplex formation and structure, including recent reports of non-canonical G-quadruplex structures. Improved methods of detection will likely further expand this collection of novel structures and ultimately change the face of quadruplex-RNA targeting as a therapeutic strategy.

Publication metadata

Author(s): Lightfoot HL, Hagen T, Tatum NJ, Hall J

Publication type: Review

Publication status: Published

Journal: FEBS Letters

Year: 2019

Volume: 593

Issue: 16

Pages: 2083-2102

Print publication date: 01/08/2019

Online publication date: 30/07/2019

Acceptance date: 15/07/2019

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: NLM (Medline)

URL: https://doi.org/10.1002/1873-3468.13547

DOI: 10.1002/1873-3468.13547

PubMed id: 31325371

Share