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The diverse structural landscape of quadruplexes

Lookup NU author(s): Dr Natalie TatumORCiD


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© 2019 Federation of European Biochemical Societies.G-quadruplexes are secondary structures formed in G-rich sequences in DNA and RNA. Considerable research over the past three decades has led to in-depth insight into these unusual structures in DNA. Since the more recent exploration into RNA G-quadruplexes, such structures have demonstrated their in cellulo existence, function and roles in pathology. In comparison to Watson-Crick-based secondary structures, most G-quadruplexes display highly redundant structural characteristics. However, numerous reports of G-quadruplex motifs/structures with unique features (e.g. bulges, long loops, vacancy) have recently surfaced, expanding the repertoire of G-quadruplex scaffolds. This review addresses G-quadruplex formation and structure, including recent reports of non-canonical G-quadruplex structures. Improved methods of detection will likely further expand this collection of novel structures and ultimately change the face of quadruplex-RNA targeting as a therapeutic strategy.

Publication metadata

Author(s): Lightfoot HL, Hagen T, Tatum NJ, Hall J

Publication type: Review

Publication status: Published

Journal: FEBS Letters

Year: 2019

Volume: 593

Issue: 16

Pages: 2083-2102

Print publication date: 01/08/2019

Online publication date: 30/07/2019

Acceptance date: 15/07/2019

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: NLM (Medline)


DOI: 10.1002/1873-3468.13547

PubMed id: 31325371