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Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens

Lookup NU author(s): Dr James ConnollyORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2019 The Author(s). Enterohaemorrhagic Escherichia coli (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly controlled by master regulators. This system is further modulated by a number of signals that help to fine-tune virulence, including metabolic, environmental and chemical signals. Since the LEE and its master regulator, Ler, were established, there have been numerous scientific advancements in understanding the regulation and expression of virulence factors in EHEC. This review will discuss the recent advancements in this field since our previous review, with a focus on the transcriptional regulation of the LEE.

Publication metadata

Author(s): Turner NCA, Connolly JPR, Roe AJ

Publication type: Review

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2018

Volume: 47

Issue: 1

Pages: 229-238

Online publication date: 17/12/2018

Acceptance date: 13/11/2018

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd


DOI: 10.1042/BST20180546

PubMed id: 30559275