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Lookup NU author(s): James Connolly
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 The Authors Cellular Microbiology Published by John Wiley & Sons LtdType 3 secretion systems form an integral part of the arsenal of many pathogenic bacteria. These injection machines, together with their cargo of subversive effector proteins, are capable of manipulating the cellular environment of the host in order to ensure persistence of the pathogen. In order to fully appreciate the functions of Type 3 effectors, it is necessary to gain spatio-temporal knowledge of each effector during the process of infection. A number of genetic modifications have been exploited in order to reveal effector protein secretion, translocation and subsequent activity, and localisation within host cells. In this review, we will discuss the many available approaches for tracking effector protein dynamics and discuss the challenges faced to improve the current technologies and gain a clearer picture of effector protein function.
Author(s): O'Boyle N, Connolly JPR, Roe AJ
Publication type: Review
Publication status: Published
Journal: Cellular Microbiology
Print publication date: 01/01/2018
Online publication date: 31/10/2017
Acceptance date: 26/10/2017
ISSN (print): 1462-5814
ISSN (electronic): 1462-5822
Publisher: Blackwell Publishing Ltd
PubMed id: 29087624